Hormones and Aging: An Endocrine Society Scientific Statement

被引：42

作者：

Cappola, Anne R. ^{[1
,14
]}

Auchus, Richard J. ^{[2
,3
]}

El-Hajj Fuleihan, Ghada ^{[4
]}

Handelsman, David J. ^{[5
,6
]}

Kalyani, Rita R. ^{[7
]}

McClung, Michael ^{[8
,9
]}

Stuenkel, Cynthia A. ^{[10
]}

Thorner, Michael O. ^{[11
,12
]}

Verbalis, Joseph G. ^{[13
]}

机构：

[1] Univ Penn, Perelman Sch Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] Univ Michigan, Dept Pharmacol & Internal Med, Div Metab & Endocrinol Diabet, Ann Arbor, MI 48109 USA

[3] LTC Charles S Kettles Vet Affairs Med Ctr, Med Serv, Endocrinol & Metab Sect, Ann Arbor, MI 48015 USA

[4] Amer Univ Beirut, WHO Collaborating Ctr Metab Bone Disorders, Dept Internal Med, Div Endocrinol,Calcium Metab & Osteoporosis Progra, Beirut 11072020, Lebanon

[5] Univ Sydney, ANZAC Res Inst, Sydney, NSW 2139, Australia

[6] Concord Repatriat Gen Hosp, Androl Dept, Sydney, NSW 2139, Australia

[7] Johns Hopkins Univ, Sch Med, Div Endocrinol Diabet & Metab, Baltimore, MD 21287 USA

[8] Oregon Osteoporosis Ctr, Portland, OR 97213 USA

[9] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic 3000, Australia

[10] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

[11] Univ Virginia, Div Endocrinol & Metab, Charlottesville, VA 22903 USA

[12] Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA

[13] Georgetown Univ, Med Ctr, Div Endocrinol & Metab, Washington, DC 20057 USA

[14] Univ Penn, Perelman Sch Med, Div Diabet Endocrinol & Metab, 3400 Civ Ctr Blvd,Bldg 521, Philadelphia, PA 19041 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 108卷 / 08期

关键词：

adrenal; androgen; diabetes; endocrinology; estrogen; growth hormone; water metabolism; osteoporosis; thyroid; vitamin D; VITAMIN-D SUPPLEMENTATION; SUBCLINICAL THYROID-DYSFUNCTION; SERUM 25-HYDROXYVITAMIN D; CORONARY-HEART-DISEASE; BONE-MINERAL DENSITY; VERTEBRAL COMPRESSION FRACTURES; FOLLICLE-STIMULATING-HORMONE; FREE TESTOSTERONE LEVELS; WOMEN AGED 80; OLDER MEN;

D O I：

10.1210/clinem/dgad225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple changes occur across various endocrine systems as an individual ages. The understanding of the factors that cause age-related changes and how they should be managed clinically is evolving. This statement reviews the current state of research in the growth hormone, adrenal, ovarian, testicular, and thyroid axes, as well as in osteoporosis, vitamin D deficiency, type 2 diabetes, and water metabolism, with a specific focus on older individuals. Each section describes the natural history and observational data in older individuals, available therapies, clinical trial data on efficacy and safety in older individuals, key points, and scientific gaps. The goal of this statement is to inform future research that refines prevention and treatment strategies in age-associated endocrine conditions, with the goal of improving the health of older individuals.

引用

页码：1835 / 1874

页数：40

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