Role of apolipoproteins in the pathogenesis of obesity

被引：4
作者：
Huang, Mingjing [1 ,2 ]
Zheng, Jingyi [1 ,2 ]
Chen, Lijun [2 ]
You, Sufang [1 ,2 ]
Huang, Huibin [2 ,3 ]
机构：
[1] Fujian Med Univ, Clin Med Coll 2, Quanzhou, Fujian, Peoples R China
[2] Fujian Med Univ, Dept Endocrinol, Affiliated Hosp 2, Quanzhou, Fujian, Peoples R China
[3] Fujian Med Univ, Dept Endocrinol, Affiliated Hosp 2, 34 North Zhongshan Rd, Quanzhou, Fujian, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2023年 / 545卷
关键词：
Obesity; ApoA; ApoB; ApoC; ApoD; ApoE; HIGH-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; LIPID-METABOLISM; A-IV; TRANSGENIC MICE; ADIPOSE-TISSUE; APOA-I; C-III; EXPRESSION; CHOLESTEROL;
D O I：
10.1016/j.cca.2023.117359
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Obesity is a state presented by excessive accumulation and abnormal distribution of body fat, with metabolic disorders being one of its distinguishing features. Obesity is associated with dyslipidemia and apolipoproteins are important structural components of plasma lipoproteins. Apolipoproteins influence the progression of obesity by a variety of mechanisms including lipid metabolism, energy expenditure and inflammatory response. In this review, we discuss the role of apolipoproteins in obesity, mechanisms of action as well as their potential as new therapeutic targets.
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页数：9
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