Role of apolipoproteins in the pathogenesis of obesity

被引：4
作者：
Huang, Mingjing [1 ,2 ]
Zheng, Jingyi [1 ,2 ]
Chen, Lijun [2 ]
You, Sufang [1 ,2 ]
Huang, Huibin [2 ,3 ]
机构：
[1] Fujian Med Univ, Clin Med Coll 2, Quanzhou, Fujian, Peoples R China
[2] Fujian Med Univ, Dept Endocrinol, Affiliated Hosp 2, Quanzhou, Fujian, Peoples R China
[3] Fujian Med Univ, Dept Endocrinol, Affiliated Hosp 2, 34 North Zhongshan Rd, Quanzhou, Fujian, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2023年 / 545卷
关键词：
Obesity; ApoA; ApoB; ApoC; ApoD; ApoE; HIGH-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; LIPID-METABOLISM; A-IV; TRANSGENIC MICE; ADIPOSE-TISSUE; APOA-I; C-III; EXPRESSION; CHOLESTEROL;
D O I：
10.1016/j.cca.2023.117359
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Obesity is a state presented by excessive accumulation and abnormal distribution of body fat, with metabolic disorders being one of its distinguishing features. Obesity is associated with dyslipidemia and apolipoproteins are important structural components of plasma lipoproteins. Apolipoproteins influence the progression of obesity by a variety of mechanisms including lipid metabolism, energy expenditure and inflammatory response. In this review, we discuss the role of apolipoproteins in obesity, mechanisms of action as well as their potential as new therapeutic targets.
引用
收藏
页数：9
相关论文
共 101 条
  • [1] Adipose tissue and insulin resistance in obese
    Ahmed, Bulbul
    Sultana, Rifat
    Greene, Michael W.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2021, 137
  • [2] The Role of Molecular and Hormonal Factors in Obesity and the Effects of Physical Activity in Children
    Aragon-Vela, Jeronimo
    Alcala-Bejarano Carrillo, Jesus
    Moreno-Racero, Aurora
    Plaza-Diaz, Julio
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [3] Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4
    Arbones-Mainar, Jose M.
    Johnson, Lance A.
    Altenburg, Michael K.
    Kim, Hyung-Suk
    Maeda, Nobuyo
    [J]. FASEB JOURNAL, 2010, 24 (10) : 3809 - 3818
  • [4] Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review
    Benn, Marianne
    [J]. ATHEROSCLEROSIS, 2009, 206 (01) : 17 - 30
  • [5] A Modern Approach to Dyslipidemia
    Berberich, Amanda J.
    Hegele, Robert A.
    [J]. ENDOCRINE REVIEWS, 2022, 43 (04) : 611 - 653
  • [6] Apolipoprotein B48 metabolism in chylomicrons and very low-density lipoproteins and its role in triglyceride transport in normo- and hypertriglyceridemic human subjects
    Bjornson, E.
    Packard, C. J.
    Adiels, M.
    Andersson, L.
    Matikainen, N.
    Soderlund, S.
    Kahri, J.
    Hakkarainen, A.
    Lundbom, N.
    Lundbom, J.
    Sihlbom, C.
    Thorsell, A.
    Zhou, H.
    Taskinen, M. -R.
    Boren, J.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2020, 288 (04) : 422 - 438
  • [7] VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells
    Botteri, Gaia
    Montori, Marta
    Guma, Anna
    Pizarro, Javier
    Cedo, Lidia
    Carles Escola-Gil, Joan
    Li, Diana
    Barroso, Emma
    Palomer, Xavier
    Kohan, Alison B.
    Vazquez-Carrera, Manuel
    [J]. DIABETOLOGIA, 2017, 60 (11) : 2262 - 2273
  • [8] Cholesterol metabolism: a new molecular switch to control inflammation
    Cardoso, Diana
    Perucha, Esperanza
    [J]. CLINICAL SCIENCE, 2021, 135 (11) : 1389 - 1408
  • [9] Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance
    Castellani, LW
    Goto, AM
    Lusis, AJ
    [J]. DIABETES, 2001, 50 (03) : 643 - 651
  • [10] Apolipoprotein CIII and diabetes. Is there a link?
    Christopoulou, Eliza
    Tsimihodimos, Vasilios
    Filippatos, Theodosios
    Elisaf, Moses
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2019, 35 (03)
12345678910