Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy

被引：1

作者：

Chan, Wei-Jen ^{[1
]}

Bupphathong, Sasinan ^{[2
]}

Cho, Han-Lin ^{[2
]}

Goudar, Venkanagouda S. ^{[2
]}

Dehestani, Sina ^{[1
]}

Chiang, Chi-Shiun ^{[3
]}

Tseng, Fan-Gang ^{[2
]}

机构：

[1] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[2] Natl Tsing Hua Univ, Engn & Syst Sci, Hsinchu 30013, Taiwan

[3] Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 30013, Taiwan

来源：

NANOMEDICINE | 2023年 / 18卷 / 09期

关键词：

BNCT; boric acid; head and neck cancer; polymeric nanoparticles; poly(vinyl alcohol); SIALIC ACIDS; NECK-CANCER; BIODISTRIBUTION; BPA; HEAD; BSH;

D O I：

10.2217/nnm-2022-0330

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. Results: The in vitro boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.

引用

页码：743 / 754

页数：12

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