Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy

被引：1
|
作者：
Chan, Wei-Jen [1 ]
Bupphathong, Sasinan [2 ]
Cho, Han-Lin [2 ]
Goudar, Venkanagouda S. [2 ]
Dehestani, Sina [1 ]
Chiang, Chi-Shiun [3 ]
Tseng, Fan-Gang [2 ]
机构：
[1] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
[2] Natl Tsing Hua Univ, Engn & Syst Sci, Hsinchu 30013, Taiwan
[3] Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 30013, Taiwan
来源：
NANOMEDICINE | 2023年 / 18卷 / 09期
关键词：
BNCT; boric acid; head and neck cancer; polymeric nanoparticles; poly(vinyl alcohol); SIALIC ACIDS; NECK-CANCER; BIODISTRIBUTION; BPA; HEAD; BSH;
D O I：
10.2217/nnm-2022-0330
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. Results: The in vitro boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.
引用
收藏
页码：743 / 754
页数：12
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