Phototherapy for age-related brain diseases: Challenges, successes and future

被引：3
|
作者：
Ding, Ling [1 ]
Gu, Ziqi [1 ]
Chen, Haishu [1 ]
Wang, Panpan [1 ]
Song, Yilan [1 ]
Zhang, Xincheng [1 ]
Li, Mengyu [1 ]
Chen, Jinhan [1 ]
Han, Hongbin [3 ,4 ,5 ]
Cheng, Jianhua [2 ,5 ]
Tong, Zhiqian [1 ,5 ]
机构：
[1] Wenzhou Med Univ, Affiliated Wenzhou Kangning Hosp, Zhejiang Prov Clin Res Ctr Mental Disorders, Oujiang Lab,Zhejiang Lab Regenerat Med Vis & Brain, Wenzhou 325035, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325035, Peoples R China
[3] Peking Univ Third Hosp, Dept Radiol, Beijing, Peoples R China
[4] Peking Univ Hlth Sci Ctr, Inst Med Technol, Key Lab Magnet Resonance Imaging Equipment & Tech, NMPA Key Lab Evaluat Med Imaging Equipment & Tech, Beijing, Peoples R China
[5] Wenzhou Med Univ, Inst Aging, Sch Mental Hlth, Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325035, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2024年 / 94卷
基金：
中国国家自然科学基金;
关键词：
Phototherapy; Age -related brain diseases; Pharmaceutical interventions; Physical therapy; Photosensitive protein; LOW-LEVEL LASER; NEAR-INFRARED LIGHT; INTERSTITIAL PHOTODYNAMIC THERAPY; QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; PHOTOBIOMODULATION THERAPY; MITOCHONDRIAL DYSFUNCTION; PARKINSONS-DISEASE; OXIDATIVE STRESS; DOUBLE-BLIND;
D O I：
10.1016/j.arr.2024.102183
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brain diseases present a significant obstacle to both global health and economic progress, owing to their elusive pathogenesis and the limited effectiveness of pharmaceutical interventions. Phototherapy has emerged as a promising non-invasive therapeutic modality for addressing age-related brain disorders, including stroke, Alzheimer's disease (AD), and Parkinson's disease (PD), among others. This review examines the recent progressions in phototherapeutic interventions. Firstly, the article elucidates the various wavelengths of visible light that possess the capability to penetrate the skin and skull, as well as the pathways of light stimulation, encompassing the eyes, skin, veins, and skull. Secondly, it deliberates on the molecular mechanisms of visible light on photosensitive proteins, within the context of brain disorders and other molecular pathways of light modulation. Lastly, the practical application of phototherapy in diverse clinical neurological disorders is indicated. Additionally, this review presents novel approaches that combine phototherapy and pharmacological interventions. Moreover, it outlines the limitations of phototherapeutics and proposes innovative strategies to improve the treatment of cerebral disorders.
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页数：17
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