Genomic Imprinting and Random Monoallelic Expression

被引：1

作者：

Lobanova, Yaroslava V. ^{[1
,2
]}

Zhenilo, Svetlana V. ^{[1
]}

机构：

[1] Russian Acad Sci, Fed Res Ctr Biotechnol, Moscow 119071, Russia

[2] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2024年 / 89卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

imprinting; random monoallelic expression; DNA methylation; ZNF57; epigenetics; ZINC-FINGER PROTEINS; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; POLYCOMB GENE; MOUSE; TRANSCRIPTION; METHYLATION; ZFP57; EVOLUTION; SEQUENCE;

D O I：

10.1134/S000629792401005X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.

引用

页码：84 / 96

页数：13

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