CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study

被引:6
作者
Cui, Yongjia [1 ]
Cui, Shasha [1 ]
Lu, Wenping [1 ]
Wang, Ya'nan [1 ]
Zhuo, Zhili [1 ]
Wang, Ruipeng [1 ]
Zhang, Dongni [1 ]
Wu, Xiaoqing [1 ]
Chang, Lei [1 ]
Zuo, Xi [1 ]
Zhang, Weixuan [1 ]
Mei, Heting [1 ]
Zhang, Mengfan [1 ]
机构
[1] China Acad Chinese Med Sci, Guang Anmen Hosp, Beijing 100053, Peoples R China
基金
中国国家自然科学基金;
关键词
C-REACTIVE PROTEIN; GENETIC-VARIANTS; INTERLEUKIN-6; INFLAMMATION; ACTIVATION; SURVIVAL; PATHWAY; OXYGEN;
D O I
10.1038/s41598-024-52080-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Epidemiological studies have reported a positive association between chronic inflammation and cancer risk. However, the causal association between chronic inflammation and breast cancer (BC) risk remains unclear. Here, we performed a Mendelian randomization study to investigate the etiological role of chronic inflammation in BC risk. We acquired data regarding C-reactive protein (CRP), interleukin (IL)-1a, IL-1b, and IL-6 expression and BC related to single nucleotide polymorphisms (SNPs) from two larger consortia (the genome-wide association studies and the Breast Cancer Association Consortium). Next, we conducted the two-sample Mendelian randomization study to investigate the relationship of the abovementioned inflammatory factors with the incidence of BC. We found that genetically predicted CRP, IL-6, and IL-1a levels did not increase BC incidence (odds ratio (OR)CRP 1.06, 95% confidence interval (CI) 0.98-1.12, P = 0.2059, ORIL-6 1.05, 95% CI 0.95-1.16, P = 0.3297 and ORIL-1a 1.01, 95% CI 0.99-1.03, P = 0.2167). However, in subgroup analysis, genetically predicted IL-1b levels increased ER + BC incidence (OR 1.15, 95% CI 1.03-1.27, P = 0.0088). Our study suggested that genetically predicted IL-1b levels were found to increase ER + BC susceptibility. However, due to the support of only one SNP, heterogeneity and pleiotropy tests cannot be performed, which deserves further research.
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页数:9
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