Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

被引：2
作者：
Andrianov, Viacheslav V. [1 ,2 ]
Kulchitsky, Vladimir A. [3 ]
Yafarova, Guzel G. [1 ,2 ]
Bazan, Leah V. [1 ]
Bogodvid, Tatiana K. [2 ,4 ]
Deryabina, Irina B. [2 ]
Muranova, Lyudmila N. [2 ]
Silantyeva, Dinara I. [2 ]
Arslanov, Almaz I. [2 ]
Paveliev, Mikhail N. [5 ]
Fedorova, Ekaterina V. [3 ]
Filipovich, Tatiana A. [3 ]
Nagibov, Aleksei V. [3 ]
Gainutdinov, Khalil L. [1 ,2 ]
机构：
[1] Russian Acad Sci, Zavoisky Phys Tech Inst, Kazan 420000, Russia
[2] Kazan Fed Univ, Inst Fundamental Med & Biol, Dept Human & Anim, Kazan 420000, Russia
[3] Inst Physiol, Natl Acad Sci, Brain Ctr, Minsk 220012, BELARUS
[4] Volga Reg State Univ Phys Culture Sport & Tourism, Dept Biomed Sci, Kazan 420000, Russia
[5] Univ Helsinki, Neurosci Ctr, Helsinki 00014, Finland
来源：
MOLECULES | 2023年 / 28卷 / 21期
关键词：
nitric oxide; cooper; brain stroke; spinal cord injury; electron paramagnetic resonance; ELECTRON-PARAMAGNETIC-RESONANCE; NITRIC-OXIDE PRODUCTION; DINITROSYL IRON COMPLEXES; SUBARACHNOID HEMORRHAGE; SUPEROXIDE DISMUTASES; COLLATERAL RECRUITMENT; DAMAGE; EPR; INHIBITION; ISCHEMIA;
D O I：
10.3390/molecules28217359
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.
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页数：17
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