Testosterone and the Amygdala's Functional Connectivity in Women and Men

被引:1
|
作者
Kogler, Lydia [1 ,2 ]
Mueller, Veronika I. [3 ,4 ]
Moser, Ewald [5 ]
Windischberger, Christian [5 ]
Gur, Ruben C. [6 ,7 ]
Habel, Ute [8 ,9 ]
Eickhoff, Simon B. [3 ,4 ]
Derntl, Birgit [1 ,2 ,10 ,11 ]
机构
[1] Univ Tubingen, Med Fac, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Calwer Str 14, D-72076 Tubingen, Germany
[2] German Ctr Mental Hlth DZPG, Partner Site, D-72076 Tubingen, Germany
[3] Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, D-52425 Julich, Germany
[4] Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, Med Fac, Mooren Str 5, D-40225 Dusseldorf, Germany
[5] Med Univ Vienna, High Field MR Ctr, Ctr Med Phys & Biomed Engn, Waehringer Guertel 18 20, A-1090 Vienna, Austria
[6] Univ Penn, Brain Behavior Lab, Philadelphia, PA 19104 USA
[7] Univ Penn, Perelman Sch Med, Dept Psychiat, Neurodev & Psychosis Sect, Philadelphia, PA 19104 USA
[8] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Pauwels Str 30, D-52074 Aachen, Germany
[9] Forschungszentrum Julich GmbH, JARA BRAIN Inst 1, Translat Brain Med, D-52425 Julich, Germany
[10] Univ Tubingen, LEAD Grad Sch & Network, Walter Simon Str 12, D-72074 Tubingen, Germany
[11] Int Max Planck Res Sch Mech Mental Funct & Dysfunc, Otfried Muller Str 27, D-72076 Tubingen, Germany
关键词
testosterone; amygdala; frontal cortex; occipital cortex; sex; gender; personality; resting-state; functional connectivity; functional magnetic resonance imaging; SEX-DIFFERENCES; SALIVARY TESTOSTERONE; HUMAN BRAIN; ANDROGEN RECEPTORS; PERSONALITY-TRAITS; CORTISOL RESPONSES; STRESS; ROTATION; HEALTHY; NETWORK;
D O I
10.3390/jcm12206501
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The amygdala contains androgen receptors and is involved in various affective and social functions. An interaction between testosterone and the amygdala's functioning is likely. We investigated the amygdala's resting-state functional connectivity (rsFC) network in association with testosterone in 94 healthy young adult women and men (final data available for analysis from 42 women and 39 men). Across the whole sample, testosterone was positively associated with the rsFC between the right amygdala and the right middle occipital gyrus, and it further predicted lower agreeableness scores. Significant sex differences appeared for testosterone and the functional connectivity between the right amygdala and the right superior frontal gyrus (SFG), showing higher testosterone levels with lower connectivity in women. Sex further predicted the openness and agreeableness scores. Our results show that testosterone modulates the rsFC between brain areas involved in affective processing and executive functions. The data indicate that the cognitive control of the amygdala via the frontal cortex is dependent on the testosterone levels in a sex-specific manner. Testosterone seems to express sex-specific patterns (1) in networks processing affect and cognition, and (2) in the frontal down-regulation of the amygdala. The sex-specific coupling between the amygdala and the frontal cortex in interaction with the hormone levels may drive sex-specific differences in a variety of behavioral phenomena that are further associated with psychiatric illnesses that show sex-specific prevalence rates.
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页数:18
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