Pathophysiology of Retinopathy of Prematurity

被引:12
作者
Hartnett, M. Elizabeth [1 ]
机构
[1] Stanford Univ, Byers Eye Inst, Palo Alto, CA 94305 USA
关键词
oxygen-induced retinopathy; angiogenesis; maternal-fetal interactions; growth factors; cell signaling; vascularization; ENDOTHELIAL GROWTH-FACTOR; RETINAL VASCULAR DEVELOPMENT; OXYGEN-INDUCED RETINOPATHY; RAT MODEL; INTRAVITREOUS NEOVASCULARIZATION; PRERETINAL NEOVASCULARIZATION; SUPPLEMENTAL OXYGEN; PRETERM INFANTS; CELL-DIVISION; ISCHEMIC RETINOPATHY;
D O I
10.1146/annurev-vision-093022-021420
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Retinopathy of prematurity (ROP) is a complex disease involving development of the neural retina, ocular circulations, and other organ systems of the premature infant. The external stresses of the ex utero environment also influence the pathophysiology of ROP through interactions among retinal neural, vascular, and glial cells. There is variability among individual infants and presentations of the disease throughout the world, making ROP challenging to study. The methods used include representative animal models, cell culture, and clinical studies. This article describes the impact of maternal-fetal interactions; stresses that the preterm infant experiences; and biologic pathways of interest, including growth factor effects and cell-cell interactions, on the complex pathophysiology of ROP phenotypes in developed and emerging countries.
引用
收藏
页码:39 / 70
页数:32
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