ImmCellFie: A user-friendly web-based platform to infer metabolic function from omics data

被引：3

作者：

Masson, Helen O. ^{[1
]}

Borland, David ^{[2
]}

Reilly, Jason ^{[2
]}

Telleria, Adrian ^{[2
]}

Shrivastava, Shalki ^{[2
,8
]}

Watson, Matt ^{[2
]}

Bustillos, Luthfi ^{[2
]}

Li, Zerong ^{[4
]}

Capps, Laura ^{[2
]}

Kellman, Benjamin P. ^{[3
,4
]}

King, Zachary A. ^{[1
]}

Richelle, Anne ^{[4
]}

Lewis, Nathan E. ^{[1
,4
]}

Robasky, Kimberly ^{[2
,5
,6
,7
,9
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Univ N Carolina, Renaissance Comp Inst, Chapel Hill, NC 27517 USA

[3] Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[5] Univ N Carolina, Dept Genet, Chapel H0069ll, Chapel Hill, NC 27514 USA

[6] Univ N Carolina, Sch Informat & Lib Sci, Chapel Hill, NC 27599 USA

[7] Univ N Carolina, Carolina Hlth & Informat Program, Chapel Hill, NC 27599 USA

[8] Lawrence Berkeley Natl Lab, Berkeley, CA USA

[9] Arrakis Therapeut, Waltham, MA 02451 USA

来源：

STAR PROTOCOLS | 2023年 / 4卷 / 01期

关键词：

RECONSTRUCTION;

D O I：

10.1016/j.xpro.2023.102069

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding cellular metabolism is important across biotechnology and biomedical research and has critical implications in a broad range of normal and pathological conditions. Here, we introduce the user-friendly web-based platform ImmCellFie, which allows the comprehensive analysis of metabolic functions inferred from transcriptomic or proteomic data. We explain how to set up a run using publicly available omics data and how to visualize the results. The ImmCellFie algorithm pushes beyond conventional statistical enrichment and in-corporates complex biological mechanisms to quantify cell activity.For complete details on the use and execution of this protocol, please refer to Richelle et al. (2021).1

引用

页数：23

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