Association between endometriosis and risk of type 2 diabetes: Results from the prospective E3N cohort

被引:2
作者
Vaduva, Patricia [1 ]
Laouali, Nasser [2 ,3 ,4 ]
Fagherazzi, Guy [5 ]
Gelot, Amandine [4 ]
Bonnet, Fabrice [1 ,4 ]
Kvaskoff, Marina [4 ,6 ]
机构
[1] Univ Hosp Rennes, Endocrinol Diabetol Nutr Unit, Rennes, France
[2] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Biostat & Epidemiol, Amherst, MA USA
[3] Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA USA
[4] Univ Paris Sud, Paris Saclay Univ, Exposome & Hered Team, Inserm,Gustave Roussy,UVSQ,CESP, Villejuif, Paris, France
[5] Luxembourg Inst Hlth, Dept Precis Hlth, Deep Digital Phenotyping Res Unit, Strassen, Luxembourg
[6] Gustave Roussy, Exposome & Hered Team, Espace Maurice Tubiana, Inserm,U1018, 114 Rue Edouard Vaillant, F-94805 Villejuif, France
关键词
Endometriosis; Epidemiology; Incidence; Type; 2; diabetes; PERITONEAL-FLUID; BODY-SIZE; WOMEN; SERUM; MARKERS; PROFILE;
D O I
10.1016/j.maturitas.2023.107805
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes.Study design: E3N is a prospective cohort of 98,995 French women aged 40-65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status.Results: Age at inclusion was 51 & PLUSMN; 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at in-clusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92-1.29), neither after further adjustment for family history of diabetes, hyper-tension and menopausal status (HR = 0.97;95%CI = 0.80-1.16). The relationship did not differ by age at in-clusion, BMI, infertility treatment, diet or menopausal status (p > 0.05).Conclusions: Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
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页数:6
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