Tumor Cell-derived Extracellular Vesicles in Modulating Phenotypes and Immune Functions of Macrophages: Mechanisms and Therapeutic Applications

被引:12
|
作者
Tian, Jia-Wen [1 ,2 ]
Zhang, He-Jing [1 ,2 ]
Li, Si-Yuan [1 ,2 ]
Guo, Yong-Lin [1 ,2 ]
Chen, Gang [1 ,2 ,3 ,4 ,5 ]
Yu, Zi-Li [1 ,2 ,3 ]
机构
[1] Wuhan Univ, State Key Lab Breeding Base Basic Sci Stomatol Hub, Wuhan, Peoples R China
[2] Wuhan Univ, Sch & Hosp Stomatol, Key Lab Oral Biomed, Minist Educ, Wuhan 430079, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Wuhan 430079, Peoples R China
[4] Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan 430071, Peoples R China
[5] Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Wuhan 430071, Peoples R China
来源
JOURNAL OF CANCER | 2023年 / 14卷 / 08期
基金
中国国家自然科学基金;
关键词
Extracellular vesicles; tumor cell; macrophage; intercellular communication; therapeutic application; PRE-METASTATIC NICHE; PLASMA-MEMBRANE; EXOSOMES; POLARIZATION; INHIBITION; BODY; IMMUNOSUPPRESSION; EXPRESSION; CHALLENGES; RECEPTORS;
D O I
10.7150/jca.84632
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor tissues consist of tumor cells and tumor stroma, which is structured by non-tumor cells and the extracellular matrix. Macrophages are the predominant immune cells in the tumor microenvironment (TME). Based on the intimate interaction between macrophages and tumor cells, macrophages are closely involved in tumor initiation and progression, playing a key role in tumor formation, angiogenesis, metastasis, and immune escape. Extracellular vesicles (EVs) are a group of membrane-enclosed structures secreted by almost all cell types. As crucial mediators of cell-to-cell communication, EVs play a role in various physiological processes and the development of diseases including cancer. According to numerous studies, tumor cell-derived extracellular vesicles (T-EVs) could highly modulate the phenotypes and functions of macrophages, thus promoting tumor development. Herein, we comprehensively introduce the role of T-EVs in regulating the M1/M2 phenotypes and immune functions of macrophages, including cytokine secretion, expression of immune regulatory molecules on the membrane, phagocytosis, and antigen presentation. More importantly, based on the regulatory effects of T-EVs on macrophages, we propose several potential therapeutic approaches that may guide future attempts to increase the effectiveness of cancer therapy.
引用
收藏
页码:1321 / 1334
页数:14
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