Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure

被引：26

作者：

Zhou, Xiaolu ^{[1
]}

Gao, Shuo ^{[1
]}

Yue, Mengjie ^{[1
]}

Zhu, Shuyun ^{[1
]}

Liu, Qian ^{[2
]}

Zhao, Xian-En ^{[1
]}

机构：

[1] Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal Shandong Prov, Qufu 273165, Shandong, Peoples R China

[2] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2023年 / 160卷

基金：

中国国家自然科学基金;

关键词：

Oxidative stress; Biomarker; Pollutant exposure; Human health risk; Reactive oxygen species; Antioxidant; Oxidative damage; URINARY PHTHALATE METABOLITES; BISPHENOL-A CONCENTRATIONS; REACTIVE OXYGEN; MASS-SPECTROMETRY; DNA-DAMAGE; SUPEROXIDE-DISMUTASE; AIR-POLLUTION; FLUORESCENCE PROBES; CARBONYL-COMPOUNDS; HYDROXYL RADICALS;

D O I：

10.1016/j.trac.2023.116978

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Exposure to environmental pollutants poses a great threat to human health. Oxidative stress is one of the widely accepted toxicity mechanisms of pollutants, and oxidative stress biomarkers provide tools for tracing the adverse effects of pollutant exposure. In this review, we focus on five kinds of typical oxidative stress biomarkers induced by pollutant exposure, including ROS, antioxidants, oxidative DNA damages, oxidative protein damages and oxidative lipid damages. We will summarize and review the application progress of various analytical methods mainly in the past decade. We also comprehensively discuss and compare their advantages and potential disadvantages. In addition, several novel analytical techniques, such as DNA damage sequencing, chemical isotope labeling, and mass spectrometry imaging, have been applied to the analysis of the biomarkers with different degrees of success. Therefore, a broader prospect is anticipated for oxidative stress biomarkers in the field of health risk assessment of pollutants.(c) 2023 Elsevier B.V. All rights reserved.

引用

页数：21

共 198 条

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