Recent advance of herbal medicines in cancer- a molecular approach

被引：45

作者：

Ali, Mohammad ^{[1
]}

Wani, Shahid Ud Din ^{[2
]}

Salahuddin, Md ^{[3
]}

Manjula, S. N. ^{[4
]}

Mruthunjaya, K. ^{[5
]}

Dey, Tathagata ^{[6
]}

Zargar, Mohammed Iqbal ^{[2
]}

Singh, Jagadeesh ^{[7
]}

机构：

[1] East Point Coll Pharm, Dept Pharm Practice, Bangalore 560049, India

[2] Univ Kashmir, Sch Appl Sci & Technol, Dept Pharmaceut Sci, Srinagar 190006, India

[3] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, India

[4] JSS Acad Higher Educ & Res, JSS Coll Pharm Mysuru, Dept Pharmacol, Mysuru 570004, India

[5] JSS Acad Higher Educ & Res, JSS Coll Pharm Mysuru, Dept Pharmacognosy, Mysuru 570004, India

[6] East Point Coll Pharm, Dept Pharmaceut Chem, Bangalore 560049, India

[7] East Point Coll Pharm, Dept Pharmacognosy, Bangalore 560049, India

来源：

HELIYON | 2023年 / 9卷 / 02期

关键词：

Anticancer; Phytochemicals; Pharmacology; Autophagy; Apoptosis; Molecular mechanism; TRADITIONAL CHINESE MEDICINE; NF-KAPPA-B; EARLY BREAST-CANCER; CELL LUNG-CANCER; ST-JOHNS-WORT; PROSTATE-CANCER; PROTECTIVE AUTOPHAGY; PANCREATIC-CANCER; CRYSTAL-STRUCTURE; COMPLEMENTARY/ALTERNATIVE MEDICINE;

D O I：

10.1016/j.heliyon.2023.e13684

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and apoptosis, involved in the underlying pathobiology of cancer development and regulation. The pharmaco-logical aiming of the autophagy-apoptosis signaling pathway using phytocompounds hence offers an auspicious method that is complementary to conventional cancer chemotherapy. The current review aims to explore the molecular level of the autophagic-apoptotic pathway to know its implication in the pathobiology of cancer and explore the essential cellular process as a druggable anticancer target and therapeutic emergence of naturally derived phytocompound-based anti-cancer agents. The data in the review were collected from scientific databases such as Google search, Web of Science, PubMed, Scopus, Medline, and Clinical Trials. With a broad outlook, we investigated their cutting-edge scientifically revealed and/or searched pharmacologic effects, a novel mechanism of action, and molecular signaling pathway of phytochemicals in cancer ther-apy. In this review, the evidence is focused on molecular pharmacology, specifically caspase, Nrf2, NF-kB, autophagic-apoptotic pathway, and several mechanisms to understand their role in cancer biology.

引用

页数：23

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