Total Synthesis of Okaspirodiol

被引：0
|
作者：
Madasu, Madhu [1 ]
Mohapatra, Debendra K. [1 ]
机构：
[1] Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, CSIR, Hyderabad 500007, India
来源：
CHEMISTRYSELECT | 2023年 / 8卷 / 13期
关键词：
Acid-catalyzed spiroketalization; Okaspirodiol; Sharpless asymmetric epoxidation; Spiroketal; Wittig reaction; ENANTIOSELECTIVE SYNTHESIS; BIOLOGICAL-ACTIVITY; SECONDARY ALCOHOLS; NATURAL-PRODUCTS; REVEROMYCIN-A; BIOSYNTHESIS; CHEMISTRY; GROWTH;
D O I：
10.1002/slct.202300352
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The asymmetric total synthesis of okaspirodiol was achieved following Sharpless asymmetric epoxidation, Gilman reaction, Wittig reaction, Horner-Wadsworth-Emmons olefination, and coupling of alkyne with the aldehyde, and acid-catalyzed spiroketalization as key reactions.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Total Synthesis of (-)-NakadomarinA
    Clark, J. Stephen
    Xu, Chao
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (13) : 4332 - 4335
  • [22] Total Synthesis of Astellatol
    Zhao, Nan
    Yin, Shuqiang
    Xie, Shengling
    Yan, Hao
    Ren, Pan
    Chen, Gui
    Chen, Fang
    Xu, Jing
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (13) : 3386 - 3390
  • [23] Total Synthesis of (-)-Pyrenophorol
    Yadav, Jhillu S.
    Reddy, Ganapuram Madhusudhan
    Rao, Tenneti Srinivasa
    Reddy, Basi V. Subba
    Al Ghamdi, Ahmad Al Khazim
    SYNTHESIS-STUTTGART, 2012, 44 (05): : 783 - 787
  • [24] Total Synthesis of Pactamycin
    Hanessian, Stephen
    Vakiti, Ramkrishna Reddy
    Dorich, Stephane
    Banerjee, Shyamapada
    Lecomte, Fabien
    DelValle, Juan R.
    Zhang, Jianbin
    Deschenes-Simard, Benoit
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (15) : 3497 - 3500
  • [25] Total Synthesis of Isoprostanes Derived from Adrenic Acid and EPA
    Oger, Camille
    Bultel-Ponce, Valerie
    Guy, Alexandre
    Durand, Thierry
    Galano, Jean-Marie
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (13) : 2621 - 2634
  • [26] Enantioselective Total Synthesis of the Putative Biosynthetic Intermediate Ambruticin J
    Trentadue, Kathryn
    Chang, Chia-Fu
    Nalin, Ansel
    Taylor, Richard E.
    CHEMISTRY-A EUROPEAN JOURNAL, 2021, 27 (43) : 11126 - 11131
  • [27] Total Synthesis of Catunaregin and Preliminary Evaluation of Its Antitumor Activity
    Abe, Hideki
    Hikichi, Takuma
    Emori, Kosuke
    Yokosuka, Akihito
    Mimaki, Yoshihiro
    Kobayashi, Toyoharu
    Ito, Hisanaka
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 2018 (14) : 1655 - 1664
  • [28] Asymmetric Total Synthesis of Distaminolyne A and Revision of Its Absolute Configuration
    Sun, Dong-Yu
    Han, Guan-Ying
    Gong, Jing-Xu
    Nay, Bastien
    Li, Xu-Wen
    Guo, Yue-Wei
    ORGANIC LETTERS, 2017, 19 (03) : 714 - 717
  • [29] Biosynthesis and Total Synthesis Studies on the Jadomycin Family of Natural Products
    Sharif, Ehesan U.
    O'Doherty, George A.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (11) : 2095 - 2108
  • [30] Total Synthesis of a 6,6-Spiroketal Metabolite, Dinemasone A
    Reddy, Chada Raji
    Srikanth, Boinapally
    Dilipkumar, Uredi
    Rao, Kakita Veera Mohana
    Jagadeesh, Bharatam
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (03) : 525 - 532
12345