Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

被引：14
作者：
Shiau, Jun-Ping [1 ]
Chuang, Ya-Ting [2 ]
Yen, Ching-Yu [3 ,4 ]
Chang, Fang-Rong [5 ]
Yang, Kun-Han [5 ]
Hou, Ming-Feng [1 ,6 ]
Tang, Jen-Yang [7 ,8 ]
Chang, Hsueh-Wei [2 ,6 ,9 ,10 ]
机构：
[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Breast Oncol & Surg, Kaohsiung 80708, Taiwan
[2] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
[3] Taipei Med Univ, Sch Dent, Taipei 11031, Taiwan
[4] Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg, Tainan 71004, Taiwan
[5] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan
[6] Kaohsiung Med Univ, Coll Life Sci, Dept Biomed Sci & Environm Biol, Kaohsiung 80708, Taiwan
[7] Kaohsiung Med Univ, Sch Postbaccalaureate Med, Kaohsiung 80708, Taiwan
[8] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Radiat Oncol, Kaohsiung 80708, Taiwan
[9] Natl Sun Yat sen Univ, Inst Med Sci & Technol, Kaohsiung 80424, Taiwan
[10] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung 80708, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
基金：
英国科研创新办公室;
关键词：
AKT; miRNA; bioactive substance; natural products; cell function; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION; PROMOTES APOPTOSIS; UP-REGULATION; DNA-REPAIR; SIGNALING PATHWAY; DOWN-REGULATION; LUNG-CANCER; C-MYC; AUTOPHAGY;
D O I：
10.3390/ijms24043688
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.
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页数：27
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