The effects of N6-methyladenosine RNA methylation on the nervous system

被引：6
作者：
Shao, Nan [1 ]
Ye, Ting [1 ]
Xuan, Weiting [2 ]
Zhang, Meng [1 ]
Chen, Qian [1 ]
Liu, Juan [3 ]
Zhou, Peng [1 ,4 ,5 ,6 ]
Song, Hang [1 ,4 ,5 ,6 ]
Cai, Biao [1 ,4 ,5 ,6 ]
机构：
[1] Anhui Univ Chinese Med, Coll Integrated Chinese & Western Med, Hefei 230012, Peoples R China
[2] Anhui Hosp Integrated Chinese & Western Med, Dept Neurosurg Rehabil, Hefei 230031, Peoples R China
[3] Taihe Cty Peoples Hosp, Dept Chinese Internal Med, Fuyang 236699, Peoples R China
[4] Anhui Acad Chinese Med, Inst Integrated Chinese & Western Med, Hefei 230012, Peoples R China
[5] Anhui Univ Chinese Med, Key Lab Xinan Med, Minist Educ, Hefei 230012, Peoples R China
[6] Anhui Prov Key Lab Chinese Med Formula, Hefei 230012, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2023年 / 478卷 / 12期
基金：
中国国家自然科学基金;
关键词：
m(6)A methylation; RNA epigenetics; Modification enzyme; Nervous system; MESSENGER-RNA; M(6)A MODIFICATION; SELF-RENEWAL; NUCLEAR-RNA; STRUCTURAL BASIS; TRANSLATION; METTL3; DIFFERENTIATION; STABILITY; PROTEINS;
D O I：
10.1007/s11010-023-04691-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epitranscriptomics, also known as "RNA epigenetics", is a type of chemical modification that regulates RNA. RNA methylation is a significant discovery after DNA and histone methylation. The dynamic reversible process of m(6)A involves methyltransferases (writers), m(6)A binding proteins (readers), as well as demethylases (erasers). We summarized the current research status of m(6)A RNA methylation in the neural stem cells' growth, synaptic and axonal function, brain development, learning and memory, neurodegenerative diseases, and glioblastoma. This review aims to provide a theoretical basis for studying the mechanism of m(6)A methylation and finding its potential therapeutic targets in nervous system diseases.
引用
收藏
页码：2657 / 2669
页数：13
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