Sustained intra-articular reactive oxygen species scavenging and alleviation of osteoarthritis by biocompatible amino-modified tantalum nanoparticles

被引:12
作者
Jiang, Yunsheng [1 ]
Li, Tao [1 ,2 ]
Yang, Junjun [1 ,3 ]
Wang, Xin [1 ]
Song, Xiongbo [1 ]
Chen, Guangxing [1 ]
Dai, Gang [1 ]
Li, Rong [2 ]
Yao, Chunyan [4 ]
Chen, Jiajia [5 ]
Chen, Cheng [6 ]
Gong, Xiaoyuan [1 ]
Yang, Liu [1 ]
机构
[1] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China
[2] Army Med Univ, Mil Med Univ 3, Inst Combined Injury, Coll Prevent Med,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China
[3] Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China
[4] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Blood Transfus Dept, Chongqing, Peoples R China
[5] Army Med Univ, Mil Med Univ 3, Biomed Anal Ctr, Chongqing, Peoples R China
[6] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China
关键词
tantalum nanoparticles; catalase activity; ROS scavenging agent; oxidative stress; osteoarthritis; NITRIC-OXIDE SYNTHASE; CHONDROCYTES; IMPLANTS; EXPRESSION; STRESS; MXENES;
D O I
10.3389/fbioe.2023.1118850
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression of osteoarthritis (OA). Attenuating oxidative stress and reducing reactive oxygen species generation in joints represent reasonable strategies for the treatment of osteoarthritis. To address the potential question for clinical translation, and improve the biocompatibility and long-term performance of current antioxidants, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity and first applied to osteoarthritis intervention. Our in vitro results showed that Ta-NH2 NPs were stable with good biocompatibility, and protected viability and hyaline-like phenotype in H2O2-challenged chondrocytes. In addition, the in vivo biodistribution data demonstrated a sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage without organ toxicity and abnormality in hemogram or blood biochemistry indexes. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced osteoarthritis model. This study preliminarily explored the potential of simply modified metal nanoparticles as effective reactive oxygen species scavenging agent for osteoarthritis intervention, and offered a novel strategy to achieve sustained reactive oxygen species suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.
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页数:15
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