共 42 条
Sustained intra-articular reactive oxygen species scavenging and alleviation of osteoarthritis by biocompatible amino-modified tantalum nanoparticles
被引:12
作者:

Jiang, Yunsheng
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Li, Tao
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China
Army Med Univ, Mil Med Univ 3, Inst Combined Injury, Coll Prevent Med,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Yang, Junjun
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China
Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Wang, Xin
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Song, Xiongbo
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Chen, Guangxing
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Dai, Gang
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Li, Rong
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Army Med Univ, Mil Med Univ 3, Inst Combined Injury, Coll Prevent Med,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Yao, Chunyan
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Blood Transfus Dept, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Chen, Jiajia
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Army Med Univ, Mil Med Univ 3, Biomed Anal Ctr, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Chen, Cheng
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Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Gong, Xiaoyuan
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China

Yang, Liu
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Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China
机构:
[1] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China
[2] Army Med Univ, Mil Med Univ 3, Inst Combined Injury, Coll Prevent Med,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China
[3] Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China
[4] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Blood Transfus Dept, Chongqing, Peoples R China
[5] Army Med Univ, Mil Med Univ 3, Biomed Anal Ctr, Chongqing, Peoples R China
[6] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China
关键词:
tantalum nanoparticles;
catalase activity;
ROS scavenging agent;
oxidative stress;
osteoarthritis;
NITRIC-OXIDE SYNTHASE;
CHONDROCYTES;
IMPLANTS;
EXPRESSION;
STRESS;
MXENES;
D O I:
10.3389/fbioe.2023.1118850
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression of osteoarthritis (OA). Attenuating oxidative stress and reducing reactive oxygen species generation in joints represent reasonable strategies for the treatment of osteoarthritis. To address the potential question for clinical translation, and improve the biocompatibility and long-term performance of current antioxidants, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity and first applied to osteoarthritis intervention. Our in vitro results showed that Ta-NH2 NPs were stable with good biocompatibility, and protected viability and hyaline-like phenotype in H2O2-challenged chondrocytes. In addition, the in vivo biodistribution data demonstrated a sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage without organ toxicity and abnormality in hemogram or blood biochemistry indexes. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced osteoarthritis model. This study preliminarily explored the potential of simply modified metal nanoparticles as effective reactive oxygen species scavenging agent for osteoarthritis intervention, and offered a novel strategy to achieve sustained reactive oxygen species suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.
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Johns Hopkins Univ, Div Cardiol, Dept Med, 720 Rutland Ave,Ross 1060, Baltimore, MD 21205 USA Johns Hopkins Univ, Div Cardiol, Dept Med, 720 Rutland Ave,Ross 1060, Baltimore, MD 21205 USA

O'Rourke, Brian
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Div Cardiol, Dept Med, 720 Rutland Ave,Ross 1060, Baltimore, MD 21205 USA Johns Hopkins Univ, Div Cardiol, Dept Med, 720 Rutland Ave,Ross 1060, Baltimore, MD 21205 USA
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Effect of porous tantalum on promoting the osteogenic differentiation of bone marrow mesenchymal stem cells in vitro through the MAPK/ERK signal pathway
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Dou, Xiaojie
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Wei, Xiaowei
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Liu, Ge
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Wang, Shuai
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Lv, Yongxiang
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Li, Junlei
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Ma, Zhijie
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Zheng, Guoshuang
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Wang, Yikai
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Hu, Minghui
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Yu, Weiting
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Zhao, Dewei
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JOURNAL OF ORTHOPAEDIC TRANSLATION,
2019, 19
:81-93

Dou, Xiaojie
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Wei, Xiaowei
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Lab Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Liu, Ge
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Lab Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Wang, Shuai
论文数: 0 引用数: 0
h-index: 0
机构:
Binzhou Peoples Hosp, Dept Orthoped, Binzhou, Shandong, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Lv, Yongxiang
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Li, Junlei
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Lab Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Ma, Zhijie
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Zheng, Guoshuang
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Dalian Univ, Lab Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Wang, Yikai
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Hu, Minghui
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Yu, Weiting
论文数: 0 引用数: 0
h-index: 0
机构:
Dalian Univ, Lab Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China

Zhao, Dewei
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h-index: 0
机构:
Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China
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Tantalum Oxide Nanoparticles for the Imaging of Articular Cartilage Using X-Ray Computed Tomography: Visualization of Ex Vivo/In Vivo Murine Tibia and Ex Vivo Human Index Finger Cartilage
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Freedman, Jonathan D.
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Lusic, Hrvoje
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Snyder, Brian D.
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Grinstaff, Mark W.
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2014, 53 (32)
:8406-8410

Freedman, Jonathan D.
论文数: 0 引用数: 0
h-index: 0
机构:
Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA
Boston Univ, Dept Pharmacol & Expt Therapeut, Boston, MA 02115 USA Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA

Lusic, Hrvoje
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h-index: 0
机构:
Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA
Boston Univ, Dept Pharmacol & Expt Therapeut, Boston, MA 02115 USA Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA

Snyder, Brian D.
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h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Adv Orthopaed Studies, Boston, MA 02115 USA Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA

Grinstaff, Mark W.
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h-index: 0
机构:
Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA
Boston Univ, Dept Pharmacol & Expt Therapeut, Boston, MA 02115 USA Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02115 USA