Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

被引：2

作者：

Zhu, Lei ^{[1
,2
,3
,4
]}

Liang, Ruimin ^{[3
,4
,5
]}

Guo, Yawen ^{[3
,4
,5
]}

Cai, Yefeng ^{[3
,4
,6
]}

Song, Fahuan ^{[3
,4
,5
]}

Hu, Yiqun ^{[3
,4
,5
]}

Liu, Yunye ^{[3
,4
,5
]}

Ge, Minghua ^{[1
,3
,4
,5
]}

Zheng, Guowan ^{[3
,4
,5
]}

机构：

[1] Soochow Univ, Suzhou Med Coll, Suzhou 215123, Jiangsu, Peoples R China

[2] Wenzhou Med Univ, Hosp 5, Lishui Cent Hosp, Dept Head & Neck Surg, Lishui 323020, Zhejiang, Peoples R China

[3] Key Lab Endocrine Gland Dis Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China

[4] Clin Res Ctr Canc Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China

[5] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Otolaryngol & Head & Neck Ctr,Canc Ctr,Dept Head &, Hangzhou 310014, Zhejiang, Peoples R China

[6] Wenzhou Med Univ, Affiliated Hosp 1, Dept Thyroid Surg, Wenzhou 325000, Zhejiang, Peoples R China

来源：

ACS OMEGA | 2024年 / 9卷 / 13期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

TARGETED THERAPY; APOPTOSIS; CELLS; IDENTIFICATION; MIGRATION; PROLIFERATION; DATABASE; DOCKING; GENES;

D O I：

10.1021/acsomega.4c00373

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.

引用

页码：15590 / 15602

页数：13

共 50 条

[41] RETRACTED: Network Pharmacology, Molecular Docking, and Experimental Validation to Unveil the Molecular Targets and Mechanisms of Compound Fuling Granule to Treat Ovarian Cancer (Retracted Article)
Li, Zhaoyi
Liu, Qingling
Zhu, Ying
Wu, Lichao
Liu, Wenhong
Li, Junfeng
Zhang, Zhiqian
Tao, Fangfang
[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
[42] Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis
Rong, Yaojun
Zhang, Guiyu
Ye, Wenhao
Qi, Linhua
Hao, Xiaojiang
Li, Xiaolin
Zhang, Wuhong
Chao, Yangfa
Gu, Shaodong
[J]. CANCER MEDICINE, 2025, 14 (06):
[43] Discovering Potential Anti-Oral Squamous Cell Carcinoma Mechanisms from Kochiae Fructus Using Network-Based Pharmacology Analysis and Experimental Validation
Kim, Youn-Sook
Lee, Jin-Choon
Lee, Minhyung
Oh, Hae-Jin
An, Won G. G.
Sung, Eui-Suk
[J]. LIFE-BASEL, 2023, 13 (06):
[44] Mechanistic Insights into the Anticancer Potential of Asparagus racemosus Willd. Against Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Study
Siddiqui, Arif Jamal
Elkahoui, Salem
Alshammari, Ahmed Mohajja
Patel, Mitesh
Ghoniem, Ahmed Eisa Mahmoud
Abdalla, Randa Abdeen Husien
Dwivedi-Agnihotri, Hemlata
Badraoui, Riadh
Adnan, Mohd
[J]. PHARMACEUTICALS, 2025, 18 (03)
[45] Integrating UPLC-Q-Exactive Orbitrap/MS, Network pharmacology and experimental validation to reveal the potential mechanism of Kadsura coccinea roots in Colon Cancer
Liu, Shi-qi
Shen, Bing-bing
Li, Hui-ying
Yao, Yu-xuan
Li, Bin
Yu, Huang-he
Tian, Xing
Zhou, Xu-dong
Sheng, Wen-bing
Mouthe, Guy Paulin Kemayou
Wang, Wei
Yang, Yu-pei
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2025, 337
[46] Mechanisms of Yiai Fuzheng formula in the treatment of triple-negative breast cancer based on UPLC-Q-Orbitrap-HRMS, network pharmacology, and experimental validation
Li, Ruijie
Ke, Haoliang
Liu, Pan
Yang, Qian
Li, Yuxin
Ke, Longzhu
Wang, Xiuping
Wu, Chaoyan
Zhang, Yingwen
[J]. HELIYON, 2024, 10 (17)
[47] Systems pharmacological study based on UHPLC-Q-Orbitrap-HRMS, network pharmacology and experimental validation to explore the potential mechanisms of Danggui-Shaoyao-San against atherosclerosis
Bi, Yiming
Han, Xin
Lai, Yigui
Fu, Yingchang
Li, Kongzheng
Zhang, Wei
Wang, Qiang
Jiang, Xuefeng
Zhou, Yingchun
Liang, Hongfeng
Fan, Huijie
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2021, 278
[48] Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking
Hu, Yu
Zhai, Wenjuan
Tan, Duanling
Chen, Haipeng
Zhang, Guiyu
Tan, Xuanjing
Zheng, Yuting
Gao, Wenhui
Wei, Yijie
Wu, Jinjun
Yang, Xin
[J]. FRONTIERS IN PHARMACOLOGY, 2023, 14
[49] Network Pharmacology Combined with Molecular Docking, Molecular Dynamics, and In Vitro Experimental Validation Reveals the Therapeutic Potential of Thymus vulgaris L. Essential Oil (Thyme Oil) against Human Breast Cancer
Alotaibi, Nahaa M.
Alotaibi, Modhi O.
Alshammari, Nawaf
Adnan, Mohd
Patel, Mitesh
[J]. ACS OMEGA, 2023, 8 (50): : 48344 - 48359
[50] Network pharmacology and molecular docking identify mechanisms of medicinal plant-derived 1,2,3,4,6-penta-O-galloyl-beta-D-glucose treating gastric cancer
Ren, Man
Yang, Yuan
Li, Dan
Zhao, Nannan
Wang, Yuping
Zhou, Yongning
[J]. BIOCELL, 2023, 47 (05) : 977 - 989

← 1 2 3 4 5 →