Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

被引：2

作者：

Zhu, Lei ^{[1
,2
,3
,4
]}

Liang, Ruimin ^{[3
,4
,5
]}

Guo, Yawen ^{[3
,4
,5
]}

Cai, Yefeng ^{[3
,4
,6
]}

Song, Fahuan ^{[3
,4
,5
]}

Hu, Yiqun ^{[3
,4
,5
]}

Liu, Yunye ^{[3
,4
,5
]}

Ge, Minghua ^{[1
,3
,4
,5
]}

Zheng, Guowan ^{[3
,4
,5
]}

机构：

[1] Soochow Univ, Suzhou Med Coll, Suzhou 215123, Jiangsu, Peoples R China

[2] Wenzhou Med Univ, Hosp 5, Lishui Cent Hosp, Dept Head & Neck Surg, Lishui 323020, Zhejiang, Peoples R China

[3] Key Lab Endocrine Gland Dis Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China

[4] Clin Res Ctr Canc Zhejiang Prov, Hangzhou 310014, Zhejiang, Peoples R China

[5] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Otolaryngol & Head & Neck Ctr,Canc Ctr,Dept Head &, Hangzhou 310014, Zhejiang, Peoples R China

[6] Wenzhou Med Univ, Affiliated Hosp 1, Dept Thyroid Surg, Wenzhou 325000, Zhejiang, Peoples R China

来源：

ACS OMEGA | 2024年 / 9卷 / 13期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

TARGETED THERAPY; APOPTOSIS; CELLS; IDENTIFICATION; MIGRATION; PROLIFERATION; DATABASE; DOCKING; GENES;

D O I：

10.1021/acsomega.4c00373

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.

引用

页码：15590 / 15602

页数：13

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