Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety

被引：3
|
作者：
Shpakovsky, Dmitry B. [1 ]
Berseneva, Daria A. [1 ]
Gracheva, Yulia A. [1 ]
Antonenko, Taisiya A. [1 ]
Oprunenko, Yury F. [1 ]
Britikov, Vladimir V. [2 ]
Britikova, Elena, V [2 ]
Milaeva, Elena R. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
[2] Natl Acad Sci Belarus, Inst Bioorgan Chem, Minsk 220084, BELARUS
来源：
MENDELEEV COMMUNICATIONS | 2024年 / 34卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
organotin complexes; abiraterone; prostate cancer; antiproliferative activity; apoptosis; cell cycle; ACETATE;
D O I：
10.1016/j.mencom.2024.01.007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N (R) Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC50 is in the range of 120-430 nM). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle.
引用
收藏
页码：22 / 24
页数：3
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