Some New Benzotriazole Derivatives: Synthesis, Antimycobacterial Evaluation, Antimicrobial Efficacy, ADME Studies, and Molecular Docking Studies

A series of new substituted phenyl-2-(perchloro-1H-benzo[d][1,2,3]triazol-1-yl)ethan-1-one derivatives 3(a-j) was synthesized, and evaluated for antimycobacterial and antimicrobial activity. Among all the tested compounds, compound 3h exhibited the highest antimycobacterial and antibacterial activity, comparable to the standard drug. Finally, the binding mode analysis of the highly active compounds was performed in the active binding site, the co-crystallized structure of Mycobacterium tuberculosis (PDB ID 2x22) and glucosamine-6-phosphate synthase (PDB ID 2VF5).