The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target

被引：9
作者：
Zhou, Xuming [1 ,2 ]
Chai, Keqiang [3 ]
Zhu, Hezhen [1 ,2 ]
Luo, Cong [1 ,2 ]
Zou, Xiaofeng [3 ,4 ,5 ]
Zou, Junrong [3 ,4 ,5 ]
Zhang, Guoxi [2 ,4 ,5 ]
机构：
[1] Gannan Med Univ, Clin Coll 1, Ganzhou 341000, Peoples R China
[2] Gannan Med Univ, Affiliated Hosp 1, Dept Urol, Ganzhou 341000, Peoples R China
[3] Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Urol, Baiyin 730900, Peoples R China
[4] Gannan Med Univ, Affiliated Hosp 1, Inst Urol, Ganzhou 341000, Peoples R China
[5] Jiangxi Engn Technol Res Ctr Calculi Prevent, Ganzhou 341000, Peoples R China
来源：
BMC CANCER | 2024年 / 24卷 / 01期
关键词：
METTL3; Prostate cancer; m6A; Drug-resistance; Biomarker; MESSENGER-RNA METHYLATION; SINGLE-NUCLEOTIDE-RESOLUTION; M(6)A METHYLTRANSFERASE; GENE-EXPRESSION; NUCLEAR-RNA; ANDROGEN RECEPTOR; M6A MODIFICATION; STRUCTURAL BASIS; TUMOR-GROWTH; PROMOTES;
D O I：
10.1186/s12885-023-11741-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming field of epigenetics. To date, more than 170 types of RNA modifications have been described, and N6-methyladenosine (m6A) is the most abundant and well-characterized internal modification of mRNAs involved in various aspects of cancer progression. METTL3, the first identified key methyltransferase, regulates human mRNA and non-coding RNA expression in an m6A-dependent manner. This review elucidates the biological function and role of METTL3 in PCa and discusses the implications of METTL3 as a potential therapeutic target for future research directions and clinical applications.
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页数：16
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