A Review on Citric Acid Production by Yarrowia lipolytica Yeast: Past and Present Challenges and Developments

被引：7

作者：

Kamzolova, Svetlana V. ^{[1
]}

机构：

[1] Russian Acad Sci, GK Skryabin Inst Biochem & Physiol Microorganisms, Pushchino Ctr Biol Res, Prospect Nauki 5, Pushchino 142290, Moscow Region, Russia

来源：

PROCESSES | 2023年 / 11卷 / 12期

关键词：

microbial synthesis; citric acid; properties and applications; Yarrowia lipolytica yeast; waste to value-added chemicals; producers; strain improvement; mutagenesis; adaptive laboratory evolution; metabolic engineering; cultivation conditions; MILL WASTE-WATER; LIPID PRODUCTION; RAW GLYCEROL; SACCHAROMYCOPSIS-LIPOLYTICA; ISOCITRIC ACIDS; CRUDE GLYCEROL; CELL RECYCLE; STRAINS; GLUCOSE; METABOLISM;

D O I：

10.3390/pr11123435

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The biosynthesis of citric acid (CA) and its derivatives is of great interest due to its wide range of applications in various manufacturing sectors. The fungus Aspergillus niger is mainly used for the commercial production of CA, using sucrose and molasses as the primary carbon sources. Since the 1960s, intensive research has been underway to introduce Yarrowia lipolytica yeast as an alternative to traditional fungal technology. This review discusses the practical uses of CA and its derivatives. Also, the challenges and developments that have led to efficient and green CA synthesis technologies using Y. lipolytica are outlined. The nutrient medium requirements and the use of various carbon sources, encompassing pure substrates and industry, agriculture, and food waste are considered. Additionally, the choice and improvement of strain producers, including efficient mutagenesis, genetic modification, and screening methods, are discussed.

引用

页数：20

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