A Review on Citric Acid Production by Yarrowia lipolytica Yeast: Past and Present Challenges and Developments

被引：7
作者：
Kamzolova, Svetlana V. [1 ]
机构：
[1] Russian Acad Sci, GK Skryabin Inst Biochem & Physiol Microorganisms, Pushchino Ctr Biol Res, Prospect Nauki 5, Pushchino 142290, Moscow Region, Russia
来源：
PROCESSES | 2023年 / 11卷 / 12期
关键词：
microbial synthesis; citric acid; properties and applications; Yarrowia lipolytica yeast; waste to value-added chemicals; producers; strain improvement; mutagenesis; adaptive laboratory evolution; metabolic engineering; cultivation conditions; MILL WASTE-WATER; LIPID PRODUCTION; RAW GLYCEROL; SACCHAROMYCOPSIS-LIPOLYTICA; ISOCITRIC ACIDS; CRUDE GLYCEROL; CELL RECYCLE; STRAINS; GLUCOSE; METABOLISM;
D O I：
10.3390/pr11123435
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The biosynthesis of citric acid (CA) and its derivatives is of great interest due to its wide range of applications in various manufacturing sectors. The fungus Aspergillus niger is mainly used for the commercial production of CA, using sucrose and molasses as the primary carbon sources. Since the 1960s, intensive research has been underway to introduce Yarrowia lipolytica yeast as an alternative to traditional fungal technology. This review discusses the practical uses of CA and its derivatives. Also, the challenges and developments that have led to efficient and green CA synthesis technologies using Y. lipolytica are outlined. The nutrient medium requirements and the use of various carbon sources, encompassing pure substrates and industry, agriculture, and food waste are considered. Additionally, the choice and improvement of strain producers, including efficient mutagenesis, genetic modification, and screening methods, are discussed.
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页数：20
相关论文
共 147 条
[1]   Metabolic engineering in the host Yarrowia lipolytica [J].
Abdel-Mawgoud, Ahmad M. ;
Markham, Kelly A. ;
Palmer, Claire M. ;
Liu, Nian ;
Stephanopoulos, Gregory ;
Alper, Hal S. .
METABOLIC ENGINEERING, 2018, 50 :192-208
[2]  
Abe M., 1970, J. Agric. Chem. Soc. Jpn, V44, P493
[3]  
Aghajanyan A.Y., 2005, Chem. J. Armen, V58, P122
[4]   PRODUCTION OF CITRIC-ACID FROM PARAFFINS BY FLUOROACETATE-SENSITIVE MUTANTS .1. INDUCTION AND CITRIC ACID PRODUCTIVITY OF FLUOROACETATE-SENSITIVE MUTANT STRAINS OF CANDIDA-LIPOLYTICA [J].
AKIYAMA, SI ;
SUZUKI, T ;
SUMINO, Y ;
NAKAO, Y ;
FUKUDA, H .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1973, 37 (04) :879-884
[5]  
Alekseeva N.A., 2018, Problems, Perspectives of Biotechnology and Biological Research, P30
[6]   Citric acid production by Candida strains under intracellular nitrogen limitation [J].
Anastassiadis, S ;
Aivasidis, A ;
Wandrey, C .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2002, 60 (1-2) :81-87
[7]   Citric acid production from partly deproteinized whey under non-sterile culture conditions using immobilized cells of lactose positive and cold-adapted Yarrowia lipolytica B9 [J].
Arslan, Nazli Pinar ;
Aydogan, Mehmet Nuri ;
Taskin, Mesut .
JOURNAL OF BIOTECHNOLOGY, 2016, 231 :32-39
[8]  
Aurich Andreas, 2003, Biotechnology Advances, V21, P454
[9]  
Aurich Andreas, 2012, Subcell Biochem, V64, P391, DOI 10.1007/978-94-007-5055-5_19
[10]  
Barth G., 1996, Genetics, Biochemistry and Molecular Biology of Non-Conventional Yeasts in Biotechnology, VVolume 1, P313
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