Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies

被引：10
|
作者：
Lu, Qianying [1 ,2 ]
Liang, Yangfan [1 ,2 ]
Tian, Sijia [1 ,2 ]
Jin, Jie [1 ,2 ]
Zhao, Yanmei [1 ,2 ]
Fan, Haojun [1 ,2 ]
机构：
[1] Tianjin Univ, Inst Disaster & Emergency Med, Tianjin 300072, Peoples R China
[2] Tianjin Key Lab Disaster Med Technol, Tianjin 300072, Peoples R China
来源：
TOXICS | 2023年 / 11卷 / 12期
基金：
中国国家自然科学基金;
关键词：
radiation; intestinal injury; injury mechanism; treatment; FECAL MICROBIOTA TRANSPLANTATION; STEREOTACTIC BODY RADIOTHERAPY; STEM-CELLS; ENDOTHELIAL APOPTOSIS; IONIZING-RADIATION; TIGHT JUNCTION; DIFFERENTIATION; IRRADIATION; CANCER; DAMAGE;
D O I：
10.3390/toxics11121011
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute RIII is essentially symptomatic and nutritional support treatment and an ideal means of prevention and treatment is lacking. Researchers have conducted studies at the cellular and animal levels and found that some chemical or biological agents have good therapeutic effects on RIII and may be used as potential candidates for clinical treatment. This article reviews the injury mechanism and potential treatment strategies based on cellular and animal experiments to provide new ideas for the diagnosis and treatment of RIII in clinical settings.
引用
收藏
页数：23
相关论文
共 50 条
  • [41] Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury
    Onal, Cem
    Kayaselcuk, Fazilet
    Topkan, Erkan
    Yavuz, Melek
    Bacanli, Didem
    Yavuz, Aydin
    DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (02) : 359 - 367
  • [42] Activation of pyroptosis and ferroptosis is involved in radiation-induced intestinal injury in mice
    Zhang, Feng
    Liu, Teng
    Huang, Hua-cui
    Zhao, Yang-yang
    He, Miao
    Yuan, Wei
    Li, Li
    Li, Jin
    Wu, Dong-ming
    Xu, Ying
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 631 : 102 - 109
  • [43] Protective Effects and Mechanisms of Action of Probiotics on Radiation-Induced Intestinal Injury
    Ming Fan
    Mei Hua Chen
    Tao Li
    JournalofNutritionalOncology, 2018, 3 (01) : 8 - 13
  • [44] Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury
    Cem Onal
    Fazilet Kayaselcuk
    Erkan Topkan
    Melek Yavuz
    Didem Bacanli
    Aydin Yavuz
    Digestive Diseases and Sciences, 2011, 56 : 359 - 367
  • [45] MODIFICATION OF RADIATION-INDUCED INTESTINAL INJURY IN RATS BY CHILLING AFTER IRRADIATION
    GUDE, WD
    UPTON, AC
    ODELL, TT
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1959, 1 (03): : 247 - 255
  • [46] Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury
    Wu, Jing
    Duan, Yuqing
    Cui, Jie
    Dong, Yinping
    Li, Hongyan
    Wang, Meifang
    Fan, Saijun
    Li, Deguan
    Li, Yiliang
    JOURNAL OF RADIATION RESEARCH, 2019, 60 (06) : 740 - 746
  • [47] Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice
    Jindal, Archana
    Agrawal, Annapurna
    Goyal, P. K.
    JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 2010, 29 (03) : 169 - 179
  • [48] Comparison of the protective effects of melatonin and octreoticle on radiation-induced intestinal injury
    Onal, C.
    Kayaselcuk, F.
    Erdem, R.
    Topkan, E.
    Yavuz, M.
    Bacanli, D.
    Yavuz, A.
    EJC SUPPLEMENTS, 2009, 7 (02): : 197 - 197
  • [49] MODIFICATION OF RADIATION-INDUCED INTESTINAL INJURY IN RATS BY CHILLING AFTER IRRADIATION
    GUDE, WD
    UPTON, AC
    RADIATION RESEARCH, 1957, 7 (03) : 319 - 320
  • [50] Swertiamarin relieves radiation-induced intestinal injury by limiting DNA damage
    Zhao, Zhe
    He, Dan
    Wang, Jinyu
    Xiao, Yu
    Gong, Lixin
    Tang, Can
    Peng, Haibo
    Qiu, Xuemei
    Liu, Rui
    Zhang, Tao
    Li, Jingyi
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, : 2277 - 2290
12345