Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies

被引：10
|
作者：
Lu, Qianying [1 ,2 ]
Liang, Yangfan [1 ,2 ]
Tian, Sijia [1 ,2 ]
Jin, Jie [1 ,2 ]
Zhao, Yanmei [1 ,2 ]
Fan, Haojun [1 ,2 ]
机构：
[1] Tianjin Univ, Inst Disaster & Emergency Med, Tianjin 300072, Peoples R China
[2] Tianjin Key Lab Disaster Med Technol, Tianjin 300072, Peoples R China
来源：
TOXICS | 2023年 / 11卷 / 12期
基金：
中国国家自然科学基金;
关键词：
radiation; intestinal injury; injury mechanism; treatment; FECAL MICROBIOTA TRANSPLANTATION; STEREOTACTIC BODY RADIOTHERAPY; STEM-CELLS; ENDOTHELIAL APOPTOSIS; IONIZING-RADIATION; TIGHT JUNCTION; DIFFERENTIATION; IRRADIATION; CANCER; DAMAGE;
D O I：
10.3390/toxics11121011
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute RIII is essentially symptomatic and nutritional support treatment and an ideal means of prevention and treatment is lacking. Researchers have conducted studies at the cellular and animal levels and found that some chemical or biological agents have good therapeutic effects on RIII and may be used as potential candidates for clinical treatment. This article reviews the injury mechanism and potential treatment strategies based on cellular and animal experiments to provide new ideas for the diagnosis and treatment of RIII in clinical settings.
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收藏
页数：23
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