Resorbable barrier polymers for flexible bioelectronics

被引：12

作者：

Mcdonald, Samantha M. ^{[1
]}

Yang, Quansan ^{[2
,3
]}

Hsu, Yen-Hao ^{[1
]}

Nikam, Shantanu P. ^{[1
]}

Hu, Ziying ^{[3
]}

Wang, Zilu ^{[4
]}

Asheghali, Darya ^{[1
]}

Yen, Tiffany ^{[1
]}

Dobrynin, Andrey V. ^{[4
]}

Rogers, John A. ^{[2
,3
,5
,6
]}

Becker, Matthew L. ^{[1
,7
,8
,9
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

[2] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[3] Northwestern Univ, Querrey Simpson Inst Bioelect, Evanston, IL 60208 USA

[4] Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA

[5] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[6] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[7] Duke Univ, Thomas Lord Dept Mech Engn & Mat Sci, Durham, NC 27708 USA

[8] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[9] Duke Univ, Dept Orthoped Surg, Durham, NC 27708 USA

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

美国国家科学基金会;

关键词：

SENSORS; TEMPERATURE;

D O I：

10.1038/s41467-023-42775-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods. While degradable magnesium-based electronics have pioneered this effort, relatively short functional lifetimes have slowed clinical translation. Barrier films that are both flexible and resorbable over predictable timelines would enable tunability in device lifetime and expand the viability of these devices. Herein, we present a library of stereocontrolled succinate-based copolyesters which leverage copolymer composition and processing method to afford tunability over thermomechanical, crystalline, and barrier properties. One copolymer composition within this library has extended the functional lifetime of transient bioelectronic prototypes over existing systems by several weeks-representing a considerable step towards translational devices. Resorbable bioelectronic devices have potential as tools for monitoring physiological parameters, but short functional lifetimes have slowed translation. Here, the authors report succinate-based copolyesters with barrier properties able to extend the functional lifetime of devices.

引用

页数：12

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