Impact of Polyphenols on Inflammatory and Oxidative Stress Factors in Diabetes Mellitus: Nutritional Antioxidants and Their Application in Improving Antidiabetic Therapy

被引:30
作者
Krawczyk, Michal [1 ]
Burzynska-Pedziwiatr, Izabela [1 ]
Wozniak, Lucyna A. [1 ]
Bukowiecka-Matusiak, Malgorzata [1 ]
机构
[1] Med Univ Lodz, Dept Struct Biol, PL-90419 Lodz, Poland
关键词
oxidative stress; inflammation; polyphenols; diabetes; MAJOR FOOD SOURCES; PANCREATIC BETA-CELLS; DNA-DAMAGE; GREEN TEA; INSULIN-RESISTANCE; GLYCEMIC CONTROL; DIETARY-INTAKE; FREE-RADICALS; RESVERATROL SUPPLEMENTATION; CUCURBITANE TRITERPENOIDS;
D O I
10.3390/biom13091402
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia and oxidative stress. Oxidative stress plays a crucial role in the development and progression of diabetes and its complications. Nutritional antioxidants derived from dietary sources have gained significant attention due to their potential to improve antidiabetic therapy. This review will delve into the world of polyphenols, investigating their origins in plants, metabolism in the human body, and relevance to the antioxidant mechanism in the context of improving antidiabetic therapy by attenuating oxidative stress, improving insulin sensitivity, and preserving beta-cell function. The potential mechanisms of, clinical evidence for, and future perspectives on nutritional antioxidants as adjuvant therapy in diabetes management are discussed.
引用
收藏
页数:30
相关论文
共 50 条
[31]   Assessment of Androgen Replacement Therapy for Erectile Function in Rats with Type 2 Diabetes Mellitus by Examining Nitric Oxide-Related and Inflammatory Factors [J].
Kataoka, Tomoya ;
Hotta, Yuji ;
Maeda, Yasuhiro ;
Kimura, Kazunori .
JOURNAL OF SEXUAL MEDICINE, 2014, 11 (04) :920-929
[32]   Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial [J].
Mahjabeen, Wajiha ;
Khan, Dilshad Ahmed ;
Mirza, Shakeel Ahmed ;
Pervez, Muhammad Amjad .
PHYTOTHERAPY RESEARCH, 2021, 35 (07) :3968-3976
[33]   Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus [J].
Jiao, Yalou ;
Zhang, Sheng ;
Zhang, Jian ;
Du, Jie .
ARCHIVES OF PHARMACAL RESEARCH, 2019, 42 (12) :1092-1100
[34]   Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus [J].
Yalou Jiao ;
Sheng Zhang ;
Jian Zhang ;
Jie Du .
Archives of Pharmacal Research, 2019, 42 :1092-1100
[35]   Oxidative stress and macrophage foam cell formation during diabetes mellitus-induced atherogenesis: Role of insulin therapy [J].
Kaplan, Marielle ;
Aviram, Michael ;
Hayek, Tony .
PHARMACOLOGY & THERAPEUTICS, 2012, 136 (02) :175-185
[36]   Animal Model of Gestational Diabetes Mellitus with Pathophysiological Resemblance to the Human Condition Induced by Multiple Factors (Nutritional, Pharmacological, and Stress) in Rats [J].
Aziz, Siti Hajar Abdul ;
John, Cini Mathew ;
Yusof, Nur Intan Saidaah Mohamed ;
Nordin, Massita ;
Ramasamy, Rajesh ;
Adam, Aishah ;
Fauzi, Fazlin Mohd .
BIOMED RESEARCH INTERNATIONAL, 2016, 2016
[37]   The role of sirtuins in the regulatin of oxidative stress during the progress and therapy of type 2 diabetes mellitus [J].
Chen, Jiawen ;
Wang, Qi ;
Li, Ruiyan ;
Li, Zhe ;
Jiang, Qizhou ;
Yan, Fangrong ;
Ye, Junmei .
LIFE SCIENCES, 2023, 333
[38]   Clinical evaluation of oxidative stress in patients with diabetes mellitus type II - impact of acute exercise [J].
Kostic, Nada ;
Caparevic, Zorica ;
Marina, Dorde ;
Ilic, Sanja ;
Radojkovic, Jana ;
Cosic, Zoran ;
Bakic-Celic, Vera .
VOJNOSANITETSKI PREGLED, 2009, 66 (06) :459-464
[39]   Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis [J].
Moslemi, Elham ;
Musazadeh, Vali ;
Kavyani, Zeynab ;
Naghsh, Navid ;
Shoura, Seyyed Morteza Seyyed ;
Dehghan, Parvin .
PHARMACOLOGICAL RESEARCH, 2022, 186
[40]   APPLICATION OF NITROXIDES AS AN ANTICANCER DRUGS AND ANTIOXIDANTS AGAINST DRUG-INDUCED OXIDATIVE STRESS IN CANCER THERAPY [J].
Lewandowski, Marcin ;
Gwozdzinski, Krzysztof .
POSTEPY BIOLOGII KOMORKI, 2015, 42 (04) :667-686