Olutasidenib: from bench to bedside

被引：16
作者：
Venugopal, Sangeetha [1 ]
Watts, Justin [1 ,2 ]
机构：
[1] Univ Miami, Sylvester Comprehens Canc Ctr, Div Hematol, Miami, FL USA
[2] Univ Miami, Sylvester Comprehens Canc Ctr, Div Hematol, Leu kemia Sect, 1120 NW 14th St,Suite 610C, Miami, FL 33136 USA
来源：
BLOOD ADVANCES | 2023年 / 7卷 / 16期
关键词：
ACUTE MYELOID-LEUKEMIA; PROGNOSTIC-SIGNIFICANCE; IDH2; MUTATIONS; SINGLE-CENTER; OUTCOMES; AZACITIDINE; VENETOCLAX; AML;
D O I：
10.1182/bloodadvances.2023009854
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The discovery of isocitrate dehydrogenase 1 (IDH1) mutations in acute myeloid leukemia (AML) and the resounding success of molecularly targeted therapies in related myeloid malignancies swiftly prompted the development of IDH1mut inhibitors. Olutasidenib (formerly known as FT-2102) is an orally administered novel IDH1mut inhibitor that entered clinical development in 2016, proceeded briskly through the developmental process, and was granted regular approval to treat patients with R/R IDH1mut AML on 1 December 2022. Single agent olutasidenib, a potent and selective IDH1mut inhibitor, demonstrated highly durable remission rates along with meaningful outcomes, such as transfusion independence, in patients with R/R IDH1mut AML. This review will examine the preclinical and clinical development and the positioning of olutasidenib in the IDH1mut AML treatment landscape.
引用
收藏
页码：4358 / 4365
页数：8
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