Systemic lupus erythematosus: From non-coding RNAs to exosomal non-coding RNAs

被引：2

作者：

Nezhad, Marzie Tabatabaie Nezhad ^{[1
]}

Rajabi, Mohammadreza ^{[2
]}

Nekooeizadeh, Pegah ^{[2
]}

Sanjari, Siavash ^{[3
,4
]}

Pourvirdi, Bita ^{[3
,4
]}

Heidari, Mohammad Mehdi ^{[4
,5
]}

Esfahani, Pegah Veradi ^{[3
,4
]}

Abdoli, Amirhossein ^{[3
,4
]}

Bagheri, Sahar ^{[6
]}

Tobeiha, Mohammad ^{[4
,5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Internal Med & Endocrinol, Tehran, Iran

[2] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[3] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

[4] Kashan Univ Med Sci, Sch Med, Kashan, Iran

[5] Kashan Univ Med Sci, Fac Med, Dept Pediat, Kashan, Iran

[6] Mazandaran Univ Med Sci, Diabet Res Ctr, Sari, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 247卷

关键词：

Systemic lupus erythematosus; Non-coding RNA; Exosome; Diagnosis; Molecular mechanisms; CD4(+) T-CELLS; NF-KAPPA-B; POTENTIAL THERAPEUTIC TARGET; BLOOD MONONUCLEAR-CELLS; INDUCIBLE FACTOR-I; CIRCULAR RNAS; DISEASE-ACTIVITY; CANCER-DIAGNOSIS; DOWN-REGULATION; CD4+T CELLS;

D O I：

10.1016/j.prp.2023.154508

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Systemic lupus erythematosus (SLE), as an immunological illness, frequently impacts young females. Both vulnerabilities to SLE and the course of the illness's clinical symptoms have been demonstrated to be affected by individual differences in non-coding RNA expression. Many non-coding RNAs (ncRNAs) are out of whack in patients with SLE. Because of the dysregulation of several ncRNAs in peripheral blood of patients suffering from SLE, these ncRNAs to be showed valuable as biomarkers for medication response, diagnosis, and activity. NcRNAs have also been demonstrated to influence immune cell activity and apoptosis. Altogether, these facts highlight the need of investigating the roles of both families of ncRNAs in the progress of SLE. Being aware of the significance of these transcripts perhaps elucidates the molecular pathogenesis of SLE and could open up promising avenues to create tailored treatments during this condition. In this review we summarized various non-coding RNAs and Exosomal non-coding RNAs in SLE.

引用

页数：13

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