Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

被引：0
|
作者：
Pandolfo, Isabella Liba [1 ]
Bonifacio, Mirian [1 ]
Benfato, Izabelle Dias [1 ]
Cruz, Matheus de Almeida [1 ]
Nagaoka, Marcia Regina [1 ]
Carvalho, Carolina Prado de Franca [1 ]
de Oliveira, Camila Aparecida Machado [1 ]
Renno, Ana Claudia Muniz [1 ,2 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, Inst Hlth & Soc, Dept Biosci, Santos, Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Rua Silva Jardim,136, Santos, SP, Brazil
来源：
JOURNAL OF BIOPHOTONICS | 2023年 / 16卷 / 11期
关键词：
glucose homeostasis; photobiomodulation; streptozotocin model; type; 1; diabetes; LEVEL LASER THERAPY; MELLITUS; RESISTANCE;
D O I：
10.1002/jbio.202300182
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Photobiomodulation (PBM) has therapeutic effects on wound healing, diabetic microangiopathy, and retinopathy. However, little is known about the use of PBM for the treatment of diabetes mellitus (DM). In this context, we aimed to evaluate the effects of PBM on pancreas morphology and insulin and glucose tolerance in an experimental model of DM. Thus, DM was induced by streptozotocin (STZ) (60 mg/kg). Subsequently, the rats were treated with PBM (808 nm and 30 J/cm(2)). After euthanasia, morphometric parameters and immunoreactivity for insulin and 8-OHdG were evaluated in the pancreas. The results showed that treated animals had higher values of body mass and higher values in the number of beta cells in the pancreas. In conclusion, PBM resulted in decreased weight loss in STZ-induced diabetic rats and presented a stimulatory effect on the pancreas of the treated animals, highlighting the promising effects of this therapy in the clinical condition of DM.
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页数：9
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