Phosphine-Mediated [3+2] Cyclization for the Synthesis of Coumarin-Based CF 3 -Containing Furanones

被引：1

作者：

Gan, Wenhao ^{[1
]}

Fu, Junfeng ^{[1
]}

Zhou, Zhixiang ^{[1
]}

Cao, Sheng ^{[1
]}

Zhang, Zhipeng ^{[1
]}

Wang, Yongjiang ^{[1
]}

Han, Xiaoyu ^{[1
]}

机构：

[1] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Zhejiang Prov Key Lab Chem & Biol Proc Technol Far, Hangzhou 310023, Peoples R China

来源：

SYNLETT | 2023年 / 34卷 / 13期

关键词：

phosphine; cyclization; coumarin; furanone; ENE-YNE-KETONES; DOMINO REACTION; 4+2 ANNULATION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; FUNCTIONALIZED COUMARIN; CATALYZED SYNTHESIS; DERIVATIVES; CYCLOADDITION; ALLENES;

D O I：

10.1055/s-0042-1751434

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tertiary phosphine-mediated [3+2] cyclization reaction of ynones with fluorinated coumarin derivatives has been developed to give a series of coumarin-based CF3-containing furanones in moderate to good yields under mild reaction conditions. Preliminary investigation into their antitumor activities is also presented.

引用

页码：1587 / 1592

页数：6

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