Application of Immobilized Enzymes in Flow Biocatalysis for Efficient Synthesis

被引：12

作者：

Tang, Zhongyao ^{[1
]}

Oku, Yuri ^{[1
]}

Matsuda, Tomoko ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Life Sci & Technol, Midori Ku, Yokohama 2268501, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2024年 / 28卷 / 05期

基金：

日本学术振兴会;

关键词：

flow chemistry; biocatalysis; enzyme immobilization; cascade reactions; CONTINUOUS KINETIC RESOLUTION; CARBON-DIOXIDE; CO2; CAPTURE; LIPASE; OPTIMIZATION; REDUCTION; KETONES; SUPPORT; CLEAS; GREEN;

D O I：

10.1021/acs.oprd.3c00405

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Flow chemistry as well as biocatalysis contribute to achieve green industries and sustainable development. Now there is an approach that combines them, called flow biocatalysis, which attracts more and more attention. In flow biocatalysis, enzyme immobilization plays a powerful role in promoting its development. This review begins with a general introduction of enzyme immobilization and then provides an update on the application of immobilized enzymes in flow biocatalysis. Oxidation-reduction, hydrolysis-esterification, transferase reaction, condensation, carboxylation, and multistep cascade reactions in a continuous-flow process are discussed in detail.

引用

页码：1308 / 1326

页数：19