Extending Dual Antiplatelet Therapy for TIA or Stroke

被引:2
作者
Kim, Anthony S. [1 ]
机构
[1] Univ Calif San Francisco, UCSF Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94143 USA
关键词
TRANSIENT ISCHEMIC ATTACK; TIME-COURSE ANALYSIS; MINOR STROKE; ASPIRIN; CLOPIDOGREL; RISK;
D O I
10.1056/NEJMe2311961
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although stroke is typically understood to be a medical emergency, the same pertains when cerebral ischemia produces seemingly mild or transient symptoms. For transient ischemic attack (TIA) and minor stroke, urgent evaluation and treatment are no less important than for larger strokes, given that the risk of recurrent stroke occurs early. Nearly half the 90-day stroke risk occurs within the first 48 hours after an event.(1) The risk is modifiable with interventions such as aspirin(2) or dual antiplatelet therapy with clopidogrel-aspirin(3,4) or ticagrelor-aspirin(5) if it is initiated within 24 hours. The trials that established the efficacy of short-term dual antiplatelet . . .
引用
收藏
页码:2478 / 2479
页数:2
相关论文
共 10 条
[1]   Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial [J].
Diener, HC ;
Bogousslavsky, J ;
Brass, LM ;
Cimminiello, C ;
Csiba, L ;
Kaste, M ;
Leys, D ;
Matias-Guiv, J ;
Rupprecht, HJ .
LANCET, 2004, 364 (9431) :331-337
[2]   Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke [J].
Gao, Ying ;
Chen, Weiqi ;
Pan, Yuesong ;
Jing, Jing ;
Wang, Chunjuan ;
Johnston, S. Claiborne ;
Amarenco, Pierre ;
Bath, Philip M. ;
Jiang, Lingling ;
Yang, Yingying ;
Wang, Tingting ;
Han, Shangrong ;
Meng, Xia ;
Lin, Jinxi ;
Zhao, Xingquan ;
Liu, Liping ;
Zhao, Jinguo ;
Li, Ying ;
Zang, Yingzhuo ;
Zhang, Shuo ;
Yang, Hongqin ;
Yang, Jianbo ;
Wang, Yuanwei ;
Li, Dali ;
Wang, Yanxia ;
Liu, Dongqi ;
Kang, Guangming ;
Wang, Yongjun ;
Wang, Yilong .
NEW ENGLAND JOURNAL OF MEDICINE, 2023, 389 (26) :2413-2424
[3]   Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack [J].
Johnston, S. Claiborne ;
Rothwell, Peter M. ;
Nguyen-Huynh, Mai N. ;
Giles, Matthew F. ;
Elkins, Jacob S. ;
Bernstein, Allan L. ;
Sidney, Stephen .
LANCET, 2007, 369 (9558) :283-292
[4]   Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA [J].
Johnston, S. Claiborne ;
Amarenco, Pierre ;
Denison, Hans ;
Evans, Scott R. ;
Himmelmann, Anders ;
James, Stefan ;
Knutsson, Mikael ;
Ladenvall, Per ;
Molina, Carlos A. ;
Wang, Yongjun .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (03) :207-217
[5]   Time Course for Benefit and Risk of Clopidogrel and Aspirin After Acute Transient Ischemic Attack and Minor Ischemic Stroke A Secondary Analysis from the POINT Randomized Trial [J].
Johnston, S. Claiborne ;
Elm, Jordan J. ;
Easton, J. Donald ;
Farrant, Mary ;
Barsan, William G. ;
Kim, Anthony S. ;
Lindblad, Anne S. ;
Palesch, Yuko Y. ;
Zurita, Karla G. ;
Albers, Gregory W. ;
Cucchiara, Brett L. ;
Kleindorfer, Dawn O. ;
Lutsep, Helmi L. ;
Pearson, Claire ;
Sethi, Pramod ;
Vora, Nirali .
CIRCULATION, 2019, 140 (08) :658-664
[6]   Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA [J].
Johnston, S. Claiborne ;
Easton, J. Donald ;
Farrant, Mary ;
Barsan, William ;
Conwit, Robin A. ;
Elm, Jordan J. ;
Kim, Anthony S. ;
Lindblad, Anne S. ;
Palesch, Yuko Y. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (03) :215-225
[7]   Risks and benefits of clopidogrel-aspirin in minor stroke or TIA Time course analysis of CHANCE [J].
Pan, Yuesong ;
Jing, Jing ;
Chen, Weiqi ;
Meng, Xia ;
Li, Hao ;
Zhao, Xingquan ;
Liu, Liping ;
Wang, David ;
Johnston, S. Claiborne ;
Wang, Yilong ;
Wang, Yongjun .
NEUROLOGY, 2017, 88 (20) :1906-1911
[8]   Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials [J].
Rothwell, Peter M. ;
Algra, Ale ;
Chen, Zhengming ;
Diener, Hans-Christoph ;
Norrving, Bo ;
Mehta, Ziyah .
LANCET, 2016, 388 (10042) :365-375
[9]   Time Course for Benefit and Risk of Ticagrelor and Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack [J].
Wang, Yongjun ;
Pan, Yuesong ;
Li, Hao ;
Amarenco, Pierre ;
Denison, Hans ;
Evans, Scott R. ;
Himmelmann, Anders ;
James, Stefan ;
Knutsson, Mikael ;
Ladenvall, Per ;
Molina, Carlos A. ;
Johnston, S. Claiborne .
NEUROLOGY, 2022, 99 (01) :E46-E54
[10]   Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack [J].
Wang, Yongjun ;
Wang, Yilong ;
Zhao, Xingquan ;
Liu, Liping ;
Wang, David ;
Wang, Chunxue ;
Wang, Chen ;
Li, Hao ;
Meng, Xia ;
Cui, Liying ;
Jia, Jianping ;
Dong, Qiang ;
Xu, Anding ;
Zeng, Jinsheng ;
Li, Yansheng ;
Wang, Zhimin ;
Xia, Haiqin ;
Johnston, S. Claiborne .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) :11-19