The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection

被引：3
|
作者：
Cuypers, L. A. B. [1 ]
Bertsch, P. [1 ]
Wang, R. [1 ]
Harhangi, H. R. [2 ]
Joziasse, L. S. [1 ]
Walboomers, X. F. [1 ]
van Niftrik, L. [2 ]
Yang, F. [1 ]
Leeuwenburgh, S. C. G. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Dent Regenerat Biomat, Philips van Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Fac Sci, Dept Microbiol, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
来源：
OPEN CERAMICS | 2023年 / 16卷
基金：
荷兰研究理事会;
关键词：
Staphylococcus aureus; Hydroxyapatite; Metal ions; Zinc; Cytocompatibility; Antibacterial properties; NANO-HYDROXYAPATITE; DOPED HYDROXYAPATITE; DELIVERY; IONS; ANTIBIOTICS; EFFICIENT; TOXICITY; SYSTEM; COPPER; SHAPE;
D O I：
10.1016/j.oceram.2023.100488
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In the face of antibiotic resistance, new antibacterial methods are urgently needed for bone infections. Local delivery of therapeutic metal ions via osteogenic nanoparticles (NPs) is a viable alternative, but high concentrations risk toxicity to mammalian cells. In this study first four ions (Mg2+, Sr2+, Cu2+, Zn2+) were assessed for cytocompatibility and antibacterial properties. Only zinc ions showed antibacterial effects at non-toxic levels. Subsequently, zinc-doped hydroxyapatite nanoparticles (ZnHA NPs) were synthesized with varying zinc content (0-20 mol%). ZnHA NPs were characterized on size, morphology, composition, and antibacterial activity, with 15 mol% ZnHA NPs exhibiting the optimal balance between cytocompatibility and antibacterial efficacy. These NPs show promise as deliverable biomaterials for bone infection treatment.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] Evaluation of Antibacterial Activity and Cytocompatibility of Ciprofloxacin Loaded Gelatin-Hydroxyapatite Scaffolds as a Local Drug Delivery System for Osteomyelitis Treatment
    Krishnan, Amit G.
    Jayaram, Lakshmi
    Biswas, Raja
    Nair, Manitha
    TISSUE ENGINEERING PART A, 2015, 21 (7-8) : 1422 - 1431
  • [32] Semiconductor photocatalytic antibacterial materials and their application for bone infection treatment
    He, Ruizhong
    Gu, Yulong
    Jia, Jiye
    Yang, Feng
    Wu, Ping
    Feng, Pei
    Shuai, Cijun
    NANOSCALE HORIZONS, 2025,
  • [33] Effect ofin ovoapplication of hydroxyapatite nanoparticles on chicken embryo development, oxidative status and bone characteristics
    Matuszewski, Arkadiusz
    Lukasiewicz, Monika
    Niemiec, Jan
    Jaworski, Slawomir
    Kamaszewski, Maciej
    Szudrowicz, Hubert
    Puppel, Kamila
    Chwalibog, Andre
    Sawosz, Ewa
    ARCHIVES OF ANIMAL NUTRITION, 2020, 74 (05) : 343 - 361
  • [34] Adverse Biological Effect of TiO2 and Hydroxyapatite Nanoparticles Used in Bone Repair and Replacement
    Wang, Jiangxue
    Wang, Liting
    Fan, Yubo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (06):
  • [35] Cu-Doped Hollow Bioactive Glass Nanoparticles for Bone Infection Treatment
    Jimenez-Holguin, Javier
    Sanchez-Salcedo, Sandra
    Cicuendez, Monica
    Vallet-Regi, Maria
    Salinas, Antonio J.
    PHARMACEUTICS, 2022, 14 (04)
  • [36] The Effect of Silver Nitrate Addition on Antibacterial Properties of Bone Scaffold Chitosan-Hydroxyapatite
    Pratama, Muhammad Adli
    Ramahdita, Ghiska
    Yuwono, Akhmad Herman
    4TH BIOMEDICAL ENGINEERING'S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM OF BIOMEDICAL ENGINEERING (ISBE) 2019, 2019, 2193
  • [37] The effect of surface treatment of hydroxyapatite on the properties of a bioactive bone cement
    J. A. Roether
    S. Deb
    Journal of Materials Science: Materials in Medicine, 2004, 15 : 413 - 418
  • [38] Insights into zinc and silver co-substitution over cytotoxicity, antibacterial efficacy, and bone regeneration capabilities of strontium phosphosilicate
    Chetan
    Vijayalakshmi, U.
    CERAMICS INTERNATIONAL, 2022, 48 (04) : 5054 - 5065
  • [39] Effect of Tb/Mg doping on composition and physical properties of hydroxyapatite nanoparticles for gene vector application
    Chen, Liang-jian
    Chen, Tian
    Cao, Jun
    Liu, Bei-lei
    Shao, Chun-sheng
    Zhou, Ke-chao
    Zhang, Dou
    TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2018, 28 (01) : 125 - 136
  • [40] Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection
    Chen, Yi-Hsuan
    Li, Tsung-Ju
    Tsai, Bo-Yang
    Chen, Liang-Kuei
    Lai, Yi-Hsin
    Li, Meng-Jia
    Tsai, Cheng-Yang
    Tsai, Pei-Jane
    Shieh, Dar-Bin
    FRONTIERS IN MICROBIOLOGY, 2019, 10
12345