The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection

被引：5

作者：

Cuypers, L. A. B. ^{[1
]}

Bertsch, P. ^{[1
]}

Wang, R. ^{[1
]}

Harhangi, H. R. ^{[2
]}

Joziasse, L. S. ^{[1
]}

Walboomers, X. F. ^{[1
]}

van Niftrik, L. ^{[2
]}

Yang, F. ^{[1
]}

Leeuwenburgh, S. C. G. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Dent Regenerat Biomat, Philips van Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Fac Sci, Dept Microbiol, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

来源：

OPEN CERAMICS | 2023年 / 16卷

基金：

荷兰研究理事会;

关键词：

Staphylococcus aureus; Hydroxyapatite; Metal ions; Zinc; Cytocompatibility; Antibacterial properties; NANO-HYDROXYAPATITE; DOPED HYDROXYAPATITE; DELIVERY; IONS; ANTIBIOTICS; EFFICIENT; TOXICITY; SYSTEM; COPPER; SHAPE;

D O I：

10.1016/j.oceram.2023.100488

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the face of antibiotic resistance, new antibacterial methods are urgently needed for bone infections. Local delivery of therapeutic metal ions via osteogenic nanoparticles (NPs) is a viable alternative, but high concentrations risk toxicity to mammalian cells. In this study first four ions (Mg2+, Sr2+, Cu2+, Zn2+) were assessed for cytocompatibility and antibacterial properties. Only zinc ions showed antibacterial effects at non-toxic levels. Subsequently, zinc-doped hydroxyapatite nanoparticles (ZnHA NPs) were synthesized with varying zinc content (0-20 mol%). ZnHA NPs were characterized on size, morphology, composition, and antibacterial activity, with 15 mol% ZnHA NPs exhibiting the optimal balance between cytocompatibility and antibacterial efficacy. These NPs show promise as deliverable biomaterials for bone infection treatment.

引用

页数：10

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