High-Resolution Enlarged Open-Bore Narrowband Magnetic Particle Imaging Based on Double-Layer Linear Scanning Structure

被引:3
作者
Bai, Shi [1 ]
Li, Tianshu [1 ]
Li, Kewen [1 ]
Gai, Lingke [1 ]
Du, Zhongzhou [2 ]
Du, Cheng [3 ]
Zhang, Wei [3 ]
Yoshida, Takashi [4 ]
Gu, Yumei [5 ]
机构
[1] Shenyang Univ Technol, Dept Informat Engn, Shenyang 110870, Peoples R China
[2] Zhengzhou Univ Light Ind, Dept Comp & Commun Engn, Zhengzhou 450066, Peoples R China
[3] Gen Hosp Northern Theater Command, Dept Oncol, Shenyang 110016, Peoples R China
[4] Kyushu Univ, Dept Elect Engn, Fukuoka 8190395, Japan
[5] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pathol, Beijing 100020, Peoples R China
基金
中国国家自然科学基金;
关键词
Superparamagnetic iron oxide nanoparticles; Spatial resolution; Image reconstruction; Harmonic analysis; Magnetic resonance imaging; Tomography; Three-dimensional displays; Enlarged field of view (FOV); magnetic particle imaging (MPI); narrowband MPI; open-bore MPI; superparamagnetic iron oxide nanoparticles (SPIONs);
D O I
10.1109/TMAG.2023.3285847
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We developed a novel high-resolution open-bore narrowband magnetic particle imaging (MPI) system for big animal and future clinical usage. Optimized strength and direction of excitation field was invested for enlarged field of view (FOV), and a 4 T/m gradient field and its linear scanning trajectory were formed by 16 square coils without coupling to excitation, forming a maximum 120 x 120 mm open bore FOV. Furthermore, a new differential pickup structure consisted of multi Helmholtz excitation and pickup coils away from the FOV was proposed in order to suppress the system noises, which was very important for the limited coil setting space in open-bore MPI. The new differential structure contributed significantly to improve the signal-to-noise ratio (SNR) as high as about 100 dB without loss of harmonic signals. Several homemade resonant circuits, filters, and lock-in amplifier were used to constitute the high-precision signal acquisition system. Experimental results showed that the detection limit of the system was 1 ug Fe of Resovist sample with a spatial resolution of 1 mm after reconstruction, satisfying many clinical needs, such as drug delivery and bedside monitoring.
引用
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页数:5
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