Association between pregnant women fasting duration and neonatal hypoglycemia: A prospective cohort study

被引：0

作者：

Makino, Yuto ^{[1
]}

Kiguchi, Takeyuki ^{[2
,3
,6
]}

Hayashi, Kazumasa ^{[4
]}

Kato, Noriko ^{[4
]}

Ueda, Kentaro ^{[5
]}

Tanaka, Taihei ^{[5
]}

Iwami, Taku ^{[2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Prevent Serv, Kyoto, Japan

[2] Kyoto Univ, Sch Publ Hlth, Dept Prevent Serv, Kyoto, Japan

[3] Trauma Ctr, Osaka Gen Med Ctr, Dept Crit Care, Osaka, Japan

[4] Nagoya Daini Hosp, Dept Obstet & Gynecol, Japanese Red Cross Aichi Med Ctr, Nagoya, Japan

[5] Nagoya Daini Hosp, Dept Pediat, Japanese Red Cross Aichi Med Ctr, Nagoya, Japan

[6] Kyoto Univ, Dept Prevent Serv, Sch Publ Hlth, Yoshida konoe cho,Sakyo ku, Kyoto 6068315, Japan

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2024年 / 165卷 / 01期

关键词：

hypoglycemia; neonates; prepartum fasting; prevention; women; LOGISTIC-REGRESSION; CESAREAN DELIVERY; GUIDELINES; OUTCOMES; PRETERM; INSULIN;

D O I：

10.1002/ijgo.15228

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To evaluate the association between maternal fasting time before delivery and the occurrence of hypoglycemia in neonates immediately after birth.Methods This prospective single-center cohort study included pregnant women who delivered at the study institution between October 2021 and January 2023 and their neonates. The primary outcome was the incidence of neonatal hypoglycemia after birth, defined as a blood glucose level less than 47 mg/dL. Fasting time was categorized into quartiles, and the association between maternal fasting time and neonatal hypoglycemia was investigated. The crude or adjusted odds ratios of maternal fasting time for neonatal hypoglycemia were calculated using logistic regression analysis.Results The study included 663 pregnant women and 696 neonates. Compared with the reference group with a short fasting time of 4.3 h or less, the adjusted odds ratios for neonatal hypoglycemia were 1.47 (95% confidence interval [CI] 0.70-3.20) for middle fasting time (4.3-9.8 h), 4.05 (95% CI 2.02-8.56) for long fasting time (9.8-14.6 h), and 4.99 (95% CI 2.59-10.25) for very long fasting time (>14.6 h). In the subgroup analysis, the association between maternal fasting time and neonatal hypoglycemia showed different trends according to the mode of delivery.Conclusion Maternal fasting time over 9-10 h before delivery was associated with the occurrence of neonatal hypoglycemia. Obstetrical management, considering not only maternal safety but also neonatal hypoglycemia prevention, is required.

引用

页码：361 / 367

页数：7