CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions

被引：0

作者：

Abdelmaged, Dalya M. M. ^{[1
]}

Avila, Carol A. ^{[2
]}

MohamedSharif, Abubaker A. ^{[3
]}

Mohammed, Isra Bdraldein Salih ^{[3
]}

机构：

[1] Al Neelain Univ, Fac Med, Khartoum, Sudan

[2] Univ Carabobo, Valencia, Venezuela

[3] Univ Khartoum, Fac Med, Khartoum, Sudan

来源：

SUDAN JOURNAL OF MEDICAL SCIENCES | 2023年 / 18卷 / 03期

关键词：

diffuse large B-cell lymphoma; leg type (DLBCL-LT); primary cutaneous diffuse large B-cell lymphoma; leg type (PCDLBCL-LT); positron emission tomography/computed tomography (PET/CT); cluster of differentiation (CD); B-cell lymphoma 2 (BCL2); B-cell lymphoma 6 (BCL6); Forkhead box P1 (FOX-P1); cmyelocytomatosis oncogene product (C-MYC); multiple myeloma oncogene 1 (MUM1); Epstein-Barr virus (EBV)-encoded RNA 1 (EBER-1);

D O I：

10.18502/sjms.v18i3.14083

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 95-year-old man came with violaceous nodular skin lesions of the left shin. The lesions were not painful or pruritic but progressed rapidly over the 3 months. Fever, night sweats, weight loss, and other systemic symptoms were absent. Shave biopsy of the lesion revealed the cells negative for CD20 but positive for BCL2, BCL6, FOX-P1, and CD10. PET/CT showed high uptake in the left leg and a sizeable hypermetabolic lymph node in the left pelvis. The patient was started on rituximab treatment as a single agent. This report highlights some of the diagnostic and treatment difficulties in CD20 negative lymphomas and the importance of a multidisciplinary approach in those cases.

引用

页码：284 / 290

页数：7

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