A regioselective synthesis of 5-difluoromethyl- and 7-difluoromethyl-substituted pyrazolo[1,5-a]pyrimidines

被引：0

作者：

Tolkunov, Valery S. ^{[1
]}

Tolkunov, Andrew S. ^{[1
]}

Smirnova, Olga V. ^{[1
]}

Tolkunov, Sergei V. ^{[1
]}

机构：

[1] L M Litvinenko Inst Phys Organ Chem & Coal Chem, Natl Acad Sci Ukraine, 50 Kharkivske shose St, UA-02160 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 59卷 / 08期

关键词：

5-aminopyrazoles; 1-cyclopropyl-4,4-difluoro-1,3-butanedione; 5-difluoromethylpyrazolo[1,5-a]pyrimidines; 7-difluoromethylpyrazolo[1,5-a]pyrimidines; 4,4-difluoro-1-phenyl-1,3-butanedione; trifluoroacetic acid; condensation; SMALL-MOLECULE INHIBITORS; FLUORINE; DERIVATIVES; AMINOPYRAZOLES; OPTIMIZATION; DISCOVERY; POTENT;

D O I：

10.1007/s10593-023-03236-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclocondensation of 3,4-substituted 5-aminopyrazoles with unsymmetrical 1,3-dicarbonyl compounds containing the difluoromethyl group in acetic acid led to 7-difluoromethylpyrazolo[1,5-a]pyrimidines, whereas 5-difluoromethylpyrazolo[1,5-a]pyrimidine derivatives were predominantly formed in trifluoroacetic acid.

引用

页码：580 / 586

页数：7

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