A regioselective synthesis of 5-difluoromethyl- and 7-difluoromethyl-substituted pyrazolo[1,5-a]pyrimidines

被引：0
作者：
Tolkunov, Valery S. [1 ]
Tolkunov, Andrew S. [1 ]
Smirnova, Olga V. [1 ]
Tolkunov, Sergei V. [1 ]
机构：
[1] L M Litvinenko Inst Phys Organ Chem & Coal Chem, Natl Acad Sci Ukraine, 50 Kharkivske shose St, UA-02160 Kiev, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 59卷 / 08期
关键词：
5-aminopyrazoles; 1-cyclopropyl-4,4-difluoro-1,3-butanedione; 5-difluoromethylpyrazolo[1,5-a]pyrimidines; 7-difluoromethylpyrazolo[1,5-a]pyrimidines; 4,4-difluoro-1-phenyl-1,3-butanedione; trifluoroacetic acid; condensation; SMALL-MOLECULE INHIBITORS; FLUORINE; DERIVATIVES; AMINOPYRAZOLES; OPTIMIZATION; DISCOVERY; POTENT;
D O I：
10.1007/s10593-023-03236-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclocondensation of 3,4-substituted 5-aminopyrazoles with unsymmetrical 1,3-dicarbonyl compounds containing the difluoromethyl group in acetic acid led to 7-difluoromethylpyrazolo[1,5-a]pyrimidines, whereas 5-difluoromethylpyrazolo[1,5-a]pyrimidine derivatives were predominantly formed in trifluoroacetic acid.
引用
收藏
页码：580 / 586
页数：7
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