Female-specific risk factors of parity and menopause age and risk of carotid plaque: the multi-ethnic study of atherosclerosis

被引:0
作者
Rodriguez, Carla P. [1 ]
Ogunmoroti, Oluseye [1 ]
Minhas, Anum S. [1 ]
Vaidya, Dhananjay [1 ]
Kazzi, Brigitte [1 ]
Osibogun, Olatokunbo [2 ]
Whelton, Seamus [1 ]
Kovell, Lara C. [3 ]
Harrington, Colleen M. [4 ]
Honigberg, Michael C. [4 ]
Thamman, Ritu [5 ]
Stein, James H. [6 ]
Shapiro, Michael D. [7 ]
Michos, Erin D. [1 ,8 ]
机构
[1] Johns Hopkins Univ, Sch Med, Ciccarone Ctr Prevent Cardiovasc Dis, Baltimore, MD USA
[2] Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Dept Epidemiol, Miami, FL USA
[3] Univ Massachusetts, Chan Med Sch, Div Gastroenterol & Hepatol, Worcester, MA USA
[4] Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA USA
[5] Univ Pittsburgh, Div Cardiol, Pittsburgh, PA USA
[6] Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
[7] Wake Forest Univ, Bowman Gray Sch Med, Ctr Preven t Cardiovasc Dis, Sect Cardiovasc Med, Winston Salem, NC USA
[8] Johns Hopkins Univ, Ciccarone Ctr Prevent Cardiovasc Dis, Sch Med, Div Cardiol, Baltimore, MD 21205 USA
来源
AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE | 2023年 / 13卷 / 04期
关键词
Parity; menopause age; carotid plaque; subclinical atherosclerosis; risk factors; women; cardiovascular disease prevention; ACUTE MYOCARDIAL-INFARCTION; ENDOGENOUS SEX-HORMONES; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; GENDER-DIFFERENCES; YOUNG-PATIENTS; ASSOCIATION; OUTCOMES; WOMEN; PROGRESSION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Female-specific factors of grand multiparity (= 5 births) and early menopause age are associated with an increased risk of cardiovascular disease (CVD). However, mechanisms are incompletely understood. Carotid plaque is a marker of subclinical atherosclerosis and associated with increased CVD risk. We evaluated the association of female-specific factors with plaque burden. Methods: We included 2,313 postmenopausal women in the Multi-Ethnic Study of Atherosclerosis, free of clinical CVD, whose parity and menopause age were ascertained by questionnaires and carotid plaque measured by ultrasound at baseline and 10 years later. Parity was categorized as nulliparity (reference), 1-2, 3-4 and = 5 live births. Menopause age was categorized as <45, 45-49, 50-54 (reference) and = 55 years. Multivariable regression was performed to evaluate the association of parity and menopause age with carotid plaque presence (yes/no) and extent [carotid plaque score (CPS)]. Results: The mean age was 64 & PLUSMN;9 years; 52.3% had prevalent carotid plaque at baseline. Compared to nulliparity, grand multiparity was significantly associated with prevalent carotid plaque after adjustment for CVD risk factors (prevalence ratio 1.17 (95% CI 1.03-1.35)) and progression of CPS over 10 years [percent difference 13% (95% CI 3-23)]. There was not any significant association of menopause age with carotid plaque presence or progression in fully-adjusted models. Conclusion: In a multiethnic cohort, grand multiparity was independently associated with carotid plaque presence and progression. Early menopause, a known risk factor for CVD, was not captured by carotid plaque in this study. These findings may have implications for refining CVD risk assessment in women.
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页码:222 / +
页数:14
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