Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells

被引:2
|
作者
Yang, Feifei [1 ]
Wen, Han [1 ]
Ma, Siqi [1 ]
Chang, Qi [1 ]
Pan, Ruile [1 ]
Liu, Xinmin [2 ]
Liao, Yonghong [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev IMPLAD, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
[2] Ningbo Univ, Inst Drug Discovery Technol, 818 Fenghua Rd, Ningbo 315211, Peoples R China
来源
MOLECULES | 2023年 / 28卷 / 15期
基金
中国国家自然科学基金;
关键词
demyelination; oligodendrocyte precursor cells differentiation; proliferation; icaritin; traditional Chinese medicine; REMYELINATION; MECHANISMS; PROTEIN; DEATH; LIFE;
D O I
10.3390/molecules28155837
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Myelin repair, which is known as remyelination, is critical to the treatment of neurodegenerative diseases, and myelination depends on not only the differentiation of oligodendrocyte precursor cells toward oligodendrocytes but also the renewal of oligodendrocyte precursor cells under pathological conditions. However, simultaneously promoting the differentiation and proliferation of oligodendrocyte precursor cells in lesions remains an unmet challenge and might affect demyelinating diseases. Kidney-tonifying herbs of traditional Chinese medicine (TCM) are effective in improving the symptoms of degenerative patients. However, herbs or compounds with dual functions are unverified. The purpose of this study was to find a kidney-tonifying TCM that synchronously improved the differentiation and proliferation of oligodendrocyte precursor cells under pathological conditions. Compounds with dual functions were screened from highly frequently used kidney-tonifying TCM, and the effects of the obtained compound on remyelination were investigated in an in vitro oligodendrocyte precursor cell differentiation model under pathological conditions and in demyelinating mice in vivo. The compound icaritin, which is an active component of Yin-Yang-Huo (the leaves of Epimedium brevicornu Maxim), demonstrated multiple effects on the remyelination process, including enhancing oligodendrocyte precursor cell proliferation, facilitating the differentiation of neural progenitor cells toward oligodendrocyte precursor cells and further toward oligodendrocytes, and maturation of oligodendrocytes under corticosterone- or glutamate-induced pathological conditions. Importantly, icaritin effectively rescued behavioral functions and increased the formation of myelin in a cuprizone-induced demyelination mouse model. The multiple effects of icaritin make it a promising lead compound for remyelination therapy.
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页数:17
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