Optimal delivery strategies for nanoparticle-mediated mRNA delivery

被引：9
作者：
Li, Xiaoyan [1 ,2 ,3 ]
Guo, Xiaocui [2 ,3 ]
Hu, Mingdi [2 ,3 ,4 ]
Cai, Rong [2 ,3 ]
Chen, Chunying [2 ,3 ,4 ,5 ]
机构：
[1] Zhengzhou Univ, Henan Inst Adv Technol, Zhengzhou 450001, Peoples R China
[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat, Beijing 100190, Peoples R China
[3] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[5] GBA Natl Inst Nanotechnol Innovat, Guangzhou 510700, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2023年 / 11卷 / 10期
基金：
中国博士后科学基金; 国家重点研发计划; 中国国家自然科学基金;
关键词：
OF-THE-ART; PROTEIN CORONA; GENE DELIVERY; IN-VIVO; LIPID NANOPARTICLES; DRUG-DELIVERY; SIRNA; PEPTIDES; EXOSOMES; POLYETHYLENIMINE;
D O I：
10.1039/d2tb02455a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Messenger RNA (mRNA) has emerged as a new and efficient agent for the treatment of various diseases. The success of lipid nanoparticle-mRNA against the novel coronavirus (SARS-CoV-2) pneumonia epidemic has proved the clinical potential of nanoparticle-mRNA formulations. However, the deficiency in the effective biological distribution, high transfection efficiency and good biosafety are still the major challenges in clinical translation of nanomedicine for mRNA delivery. To date, a variety of promising nanoparticles have been constructed and then gradually optimized to facilitate the effective biodistribution of carriers and efficient mRNA delivery. In this review, we describe the design of nanoparticles with an emphasis on lipid nanoparticles, and discuss the manipulation strategies for nanoparticle-biology (nano-bio) interactions for mRNA delivery to overcome the biological barriers and improve the delivery efficiency, because the specific nano-bio interaction of nanoparticles usually remoulds the biomedical and physiological properties of the nanoparticles especially the biodistribution, mechanism of cellular internalization and immune response. Finally, we give a perspective for the future applications of this promising technology. We believe that the regulation of nano-bio interactions would be a significant breakthrough to improve the mRNA delivery efficiency and cross biological barriers. This review may provide a new direction for the design of nanoparticle-mediated mRNA delivery systems.
引用
收藏
页码：2063 / 2077
页数：15
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