Peripheral blood kinetics following total body irradiation and allogeneic hematopoietic stem cell transplantation: Timing matters

被引：2

作者：

Dejonckheere, Cas S. ^{[1
]}

Boehner, Alexander M. C. ^{[2
]}

Schmitz, Eva ^{[3
]}

Holderried, Tobias A. W. ^{[4
]}

Schmeel, Leonard C. ^{[1
]}

Brossart, Peter ^{[4
]}

Giordano, Frank A. ^{[5
]}

Koeksal, Mumtaz A. ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Radiat Oncol, Venusberg Campus 1, D-53127 Bonn, Germany

[2] Univ Hosp Bonn, Inst Mol Med & Expt Immunol, Bonn, Germany

[3] Univ Hosp Bonn, Dept Neurol, Bonn, Germany

[4] Univ Hosp Bonn, Dept Oncol Hematol Immunooncol & Rheumatol, Bonn, Germany

[5] Univ Med Ctr Mannheim, Dept Radiat Oncol, Mannheim, Germany

来源：

CANCER MEDICINE | 2023年 / 12卷 / 06期

关键词：

acute lymphoblastic leukemia; acute myeloid leukemia; allogeneic hematopoietic stem cell transplantation; total body irradiation; ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; CONDITIONING REGIMENS; RANDOMIZED-TRIAL; GRAFT FAILURE; SURVIVAL; BUSULFAN; DISEASE;

D O I：

10.1002/cam4.5452

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Total body irradiation (TBI) remains an important component in many conditioning regimens before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because of its frequent toxicity, patient selection is crucial, making it of interest to identify factors improving engraftment. In this retrospective single center analysis, the characteristics of 48 adult such patients were studied. Mean overall survival (OS) was 22.2 months after allo-HSCT. Interestingly, people with an interval >= 3 days between TBI completion and allo-HSCT showed improved OS, when compared to a shorter interval (p = 0.10). Peripheral blood kinetics after successful engraftment also differed, with a longer interval resulting in a higher platelet count and lower leukocyte and neutrophil (p < 0.05) count. These data suggest that the exact timing of TBI before allo-HSCT might directly impact a patient's survival and could help single out those at higher risk of graft failure who might benefit from an altered conditioning regimen.

引用

页码：7170 / 7174

页数：5

共 22 条

[1] Long-term follow-up of a randomized trial comparing the combination of cyclophosphamide with total body irradiation or busulfan as conditioning regimen for patients receiving HLA-identical marrow grafts for acute myeloblastic leukemia in first complete remission [J].

Blaise, D ;

Maraninchi, D ;

Michallet, M ;

Reiffers, J ;

Jouet, JP ;

Milpied, N ;

Devergie, A ;

Attal, M ;

Sotto, JJ ;

Kuentz, M ;

Ifrah, N ;

Duriac, C ;

Bordigoni, P ;

Gratecos, N ;

Guilhot, F ;

Guyotat, D ;

Gluckman, E ;

Vernant, JP .

BLOOD, 2001, 97 (11) :3669-3671

[2] Randomized trial of busulfan vs total body irradiation containing conditioning regimens for children with acute lymphoblastic leukemia:: A Pediatric Blood and Marrow Transplant Consortium study [J].

Bunin, N ;

Aplenc, R ;

Kamani, N ;

Shaw, K ;

Cnaan, A ;

Simms, S .

BONE MARROW TRANSPLANTATION, 2003, 32 (06) :543-548

[3] Risk factors and outcome of graft failure after HLA matched and mismatched unrelated donor hematopoietic stem cell transplantation: a study on behalf of SFGM-TC and SFHI [J].

Cluzeau, T. ;

Lambert, J. ;

Raus, N. ;

Dessaux, K. ;

Absi, L. ;

Delbos, F. ;

Devys, A. ;

De Matteis, M. ;

Dubois, V. ;

Filloux, M. ;

Fort, M. ;

Hau, F. ;

Jollet, I. ;

Labalette, M. ;

Masson, D. ;

Mercier, B. ;

Pedron, B. ;

Perrier, P. ;

Picard, C. ;

Quainon, F. ;

Ramounau-Pigot, A. ;

Renac, V. ;

Van Endert, P. ;

Charron, D. ;

de la Tour, R. Peffault ;

Taupin, J. L. ;

Loiseau, P. .

BONE MARROW TRANSPLANTATION, 2016, 51 (05) :687-691

[4] Treatment Complications and Long-term Outcomes of Total Body Irradiation in Patients with Acute Lymphoblastic Leukemia: A Single Institute Experience [J].

De Felice, Francesca ;

Grapulin, Lavinia ;

Musio, Daniela ;

Pomponi, Jenny ;

Di Felice, Cinzia ;

Iori, Anna Paola ;

Bertaina, Alice ;

Tombolini, Vincenzo .

ANTICANCER RESEARCH, 2016, 36 (09) :4859-4864

[5] Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs total body irradiation:: a meta-analysis [J].

Hartman, AR ;

Williams, S ;

Dillon, JJ .

BONE MARROW TRANSPLANTATION, 1998, 22 (05) :439-443

[6] TRENDS IN UTILIZATION OF TOTAL BODY IRRADIATION (TBI) PRIOR TO HEMATOPOIETIC CELL TRANSPLANTATION (HCT) WORLDWIDE [J].

Hong, S. ;

Barker, C. ;

Klein, J. P. ;

Shaw, P. ;

Bredeson, C. ;

Angelina, A. ;

Rowlings, P. ;

Cahn, J. -Y. ;

Dabaja, Kharfan-M ;

Aljurf, M. ;

Szer, J. ;

Wood, W. A. ;

Ahmed, I ;

Gomez-Almaguer, D. ;

Atsuta, Y. ;

Pasquini, M. C. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (02) :S336-S337

[7] Current and future approaches to treat graft failure after allogeneic hematopoietic stem cell transplantation [J].

Locatelli, Franco ;

Lucarelli, Barbarella ;

Merli, Pietro .

EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (01) :23-36

[8] Pulmonary Toxicity after Total Body Irradiation-An Underrated Complication? Estimation of Risk via Normal Tissue Complication Probability Calculations and Correlation with Clinical Data [J].

Oertel, Michael ;

Kittel, Christopher ;

Martel, Jonas ;

Mikesch, Jan-Henrik ;

Glashoerster, Marco ;

Stelljes, Matthias ;

Eich, Hans Theodor .

CANCERS, 2021, 13 (12)

[9] Graft failure in the modern era of allogeneic hematopoietic SCT [J].

Olsson, R. ;

Remberger, M. ;

Schaffer, M. ;

Berggren, D. M. ;

Svahn, B-M ;

Mattsson, J. ;

Ringden, O. .

BONE MARROW TRANSPLANTATION, 2013, 48 (04) :537-543

[10] Graft failure after allogeneic hematopoietic stem cell transplantation [J].

Ozdemir, Zehra Narli ;

Bozdag, Sinem Civriz .

TRANSFUSION AND APHERESIS SCIENCE, 2018, 57 (02) :163-167

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