Immune cell-mediated venous thrombus resolution

被引：11

作者：

Henke, Peter K. ^{[1
,3
]}

Nicklas, John M. ^{[2
]}

Obi, Andrea ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Frankel Cardiovasc Ctr, Dept Surg, Ann Arbor, MI USA

[2] Brown Univ, Sch Med, Dept Med, Providence, RI 02912 USA

[3] Univ Michigan Hlth Syst, Frankel Cardiovasc Ctr, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2023年 / 7卷 / 08期

关键词：

deep vein thrombosis; fibrinolysis; inflammation; leukocytes; venous thrombosis; DEEP-VEIN THROMBOSIS; P-SELECTIN INHIBITION; UROKINASE PLASMINOGEN-ACTIVATOR; NEUTROPHIL EXTRACELLULAR TRAPS; ENDOTHELIAL PROGENITOR CELLS; MATRIX-METALLOPROTEINASE; GENE-DELETED MICE; WALL FIBROSIS; MESENCHYMAL TRANSITION; FIBROTIC INJURY;

D O I：

10.1016/j.rpth.2023.102268

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Herein, we review the current processes that govern experimental deep vein thrombus (DVT) resolution. How the human DVT resolves at the molecular and cellular level is not well known due to limited specimen availability. Experimentally, the thrombus resolution resembles wound healing, with early neutrophil-mediated actions followed by monocyte/macrophage-mediated events, including neovascularization, fibrinolysis, and eventually collagen replacement. Potential therapeutic targets are described, and coupling with site-directed approaches to mitigate off-target effects is the long-term goal. Similarly, timing of adjunctive agents to accelerate DVT resolution is an area that is only starting to be considered. There is much critical research that is needed in this area.

引用

页数：12

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