Neuroimmune pathways regulating airway inflammation

被引:4
作者
Trevizan-Bau, Pedro [1 ,2 ]
Mazzone, Stuart B. [3 ]
机构
[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia
[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia
[3] Univ Melbourne, Dept Anat & Physiol, Melbourne, Vic, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
NEUROENDOCRINE CELLS FUNCTION; SYMPATHETIC-NERVES; IMMUNE; IMPACT; COUGH; NEURONS; BRAIN; INNERVATION; DEPRESSION; RESPONSES;
D O I
10.1016/j.anai.2023.07.020
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Airways diseases are typically accompanied by inflammation, which has long been known to contribute to obstruction, mucus hypersecretion, dyspnea, cough, and other characteristic symptoms displayed in patients. Clinical interventions, therefore, often target inflammation to reverse lung pathology and reduce morbidity. The airways and lungs are densely innervated by subsets of nerve fibers, which are not only impacted by pulmonary inflammation but, in addition, likely serve as important regulators of immune cell function. This bidirectional neuroimmune crosstalk is supported by close spatial relationships between immune cells and airway nerve fibers, complementary neural and immune signaling pathways, local specialized airway chemosensory cells, and dedicated reflex circuits. In this article, we review the recent literature on this topic and present state-of-the-art evidence supporting the role of neuroimmune interactions in airway inflammation. In addition, we extend this evidence to synthesize considerations for the clinical translation of these discoveries to improve the management of patients with airway disease.(c) 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:550 / 560
页数:11
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